Seroatlas · Human Serome Atlas

RAB40C

Ras-related protein Rab-40C

Also known as: RARL, RASL8C, RB40C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S21
Gene: RAB40C
Ensembl: ENSG00000197562
Chromosome: 16
Canonical length: 281 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable GTPase activity. Predicted to be involved in exocytosis. Located in Golgi apparatus and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q96S21|RAB40C
     1  MGSQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG
    61  RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP
   121  RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM
   181  EKIWRPNRVF SLQDLCCRAI VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS
   241  YSLASGAGGG GSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB40C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

skin: 56 nTPM
cerebral cortex: 41 nTPM
pancreas: 36 nTPM
cerebellum: 35 nTPM
basal ganglia: 23 nTPM
blood vessel: 20 nTPM

Single-cell type

esophageal apical cells: 127 nCPM
corticotrophs: 106 nCPM
syncytiotrophoblasts: 102 nCPM
renal connecting tubule cells: 88 nCPM
renal collecting duct intercalated cells: 82 nCPM
foveolar cells: 81 nCPM

Immune cell

eosinophil: 14 nTPM
neutrophil: 4.9 nTPM
classical monocyte: 2.8 nTPM
MAIT T-cell: 1.9 nTPM
intermediate monocyte: 1.8 nTPM
myeloid DC: 1.6 nTPM

Brain region

cerebral cortex: 51 nTPM
hippocampal formation: 34 nTPM
basal ganglia: 34 nTPM
white matter: 32 nTPM
amygdala: 30 nTPM
cerebellum: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.02
gnomAD missense Z: 2.34
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB40C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB40C as an antibody target. Whether an autoantibody or antibody against RAB40C could matter depends on whether native RAB40C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB40C is annotated at the cell surface, where native RAB40C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB40C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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