ADSS2

Protein identityUniProt · HPA

UniProt accession

P30520

Gene

ADSS2

Ensembl

ENSG00000035687

Chromosome

1

Canonical length

456 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>P30520|ADSS2
     1  MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL AQDADIVCRC
    61  QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV IHLPGLFEEA EKNVQKGKGL
   121  EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ RQEQAGKNLG TTKKGIGPVY SSKAARSGLR
   181  MCDLVSDFDG FSERFKVLAN QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE
   241  ALHGPPKKIL VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY
   301  TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH MINGFTALAL
   361  TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV QYKTLPGWNT DISNARAFKE
   421  LPVNAQNYVR FIEDELQIPV KWIGVGKSRE SMIQLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADSS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

66 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.33

DepMap mean gene effect

-0.58

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 'de novo' AMP biosynthetic process
• AMP biosynthetic process
• aspartate metabolic process
• cellular response to electrical stimulus
• immune system process
• IMP metabolic process
• response to purine-containing compound
• response to ammonium ion

Molecular functions

• adenylosuccinate synthase activity
• GTP binding
• magnesium ion binding
• phosphate ion binding

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Adenylosuccinate synthetase
• Adenylosuccinate synthase, GTP-binding site
• P-loop containing nucleoside triphosphate hydrolase
• Adenylosuccinate synthase, active site
• Adenylosuccinate synthetase, domain 1
• Adenylosuccinate synthetase, domain 2
• Adenylosuccinate synthetase, domain 3
• Adenylosuccinate synthetase
• Adenylosuccinate synthetase isozyme 2, chordates

KeywordsUniProt

• Cytoplasm
• GTP-binding
• Ligase
• Magnesium
• Metal-binding
• Mitochondrion
• Nucleotide-binding
• Purine biosynthesis

InteractionsUniProt · HPA

Protein binding partners of ADSS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADSS1
• SMYD1