Seroatlas · Human Serome Atlas

ATAD2B

ATPase family AAA domain-containing protein 2B

Also known as: ATD2B_HUMAN, KIAA1240

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULI0
Gene: ATAD2B
Ensembl: ENSG00000119778
Chromosome: 2
Canonical length: 1458 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

1458 residues, UniProt reviewed canonical sequence.

>Q9ULI0|ATAD2B
     1  MVNTRKSSLR LLGSKSPGPG PGPGAGAEPG ATGGSSHFIS SRTRSSKTRA ASCPAAKAGG
    61  SGGAGVTLDE ARKVEVDGSL SDSHVSPPAK RTLKQPDSVC KDKSKSRSTG QREEWNLSTG
   121  QARLTSQPGA TLPNGHSGLS LRSHPLRGEK KGDGDLSCIN GDMEVRKSCR SRKNRFESVN
   181  QSLLFDQLVN STAEAVLQEM DNINIRRNRR SGEVERLRMW TDTEFENMDM YSRVKRRRKS
   241  LRRNSYGIQN HHEVSTEGEE EESQEEDGDI EVEEAEGEEN DRPYNLRQRK TVDRYQAPPI
   301  VPAHQKKREN TLFDIHRSPA RRSHIRRKKH AIHSSDTTSS DEERFERRKS KSMARARNRC
   361  LPMNFRAEDL ASGILRERVK VGASLADVDP MNIDKSVRFD SIGGLSHHIH ALKEMVVFPL
   421  LYPEIFEKFK IQPPRGCLFY GPPGTGKTLV ARALANECSQ GDKKVAFFMR KGADCLSKWV
   481  GESERQLRLL FDQAYLMRPS IIFFDEIDGL APVRSSRQDQ IHSSIVSTLL ALMDGLDNRG
   541  EIVVIGATNR LDSIDPALRR PGRFDREFLF NLPDQKARKH ILQIHTRDWN PKLSDAFLGE
   601  LAEKCVGYCG ADIKALCTEA ALIALRRRYP QIYASSHKLQ LDVSSIVLSA QDFYHAMQNI
   661  VPASQRAVMS SGHALSPIIR PLLERSFNNI LAVLQKVFPH AEISQSDKKE DIETLILEDS
   721  EDENALSIFE TNCHSGSPKK QSSSAAIHKP YLHFTMSPYH QPTSYRPRLL LSGERGSGQT
   781  SHLAPALLHT LERFSVHRLD LPALYSVSAK TPEESCAQIF REARRTVPSI VYMPHIGDWW
   841  EAVSETVRAT FLTLLQDIPS FSPIFLLSTS ETMYSELPEE VKCIFRIQYE EVLYIQRPIE
   901  EDRRKFFQEL ILNQASMAPP RRKHAALCAM EVLPLALPSP PRQLSESEKS RMEDQEENTL
   961  RELRLFLRDV TKRLATDKRF NIFSKPVDIE EVSDYLEVIK EPMDLSTVIT KIDKHNYLTA
  1021  KDFLKDIDLI CSNALEYNPD KDPGDKIIRH RACTLKDTAH AIIAAELDPE FNKLCEEIKE
  1081  ARIKRGLSVT SEQINPHSTG ARKTETRVEE AFRHKQRNPM DVWHNSANKC AFRVRRKSRR
  1141  RSQWGKGIIK KRKVNNLKKD EEDTKFADYE NHTEDRKLLE NGEFEVSTDC HEENGEETGD
  1201  LSMTNDESSC DIMDLDQGQR LNNGAGTKEN FASTEEESSN ESLLVNSSSS LNPEQTSRKE
  1261  TFLKGNCLNG EASTDSFEGI PVLECQNGKL EVVSFCDSGD KCSSEQKILL EDQSKEKPET
  1321  STENHGDDLE KLEALECSNN EKLEPGSDVE VKDAELDKEG ASKVKKYRKL ILEQAKTTSL
  1381  ELVPEEPSEP VPPLIVDRER LKKLLDLLVD KSNNLAVDQL ERLYSLLSQC IYRHRKDYDK
  1441  SQLVEEMERT VHMFETFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATAD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 9.6 nTPM
bone marrow: 9.2 nTPM
retina: 8.7 nTPM
skin: 7.8 nTPM
lymph node: 6.9 nTPM
vagina: 6.3 nTPM

Single-cell type

neutrophil progenitors: 313 nCPM
monocyte progenitors: 276 nCPM
choroid plexus epithelial cells: 274 nCPM
neutrophils: 268 nCPM
tuft cells: 254 nCPM
thymocytes: 247 nCPM

Immune cell

basophil: 16 nTPM
neutrophil: 12 nTPM
plasmacytoid DC: 11 nTPM
memory B-cell: 8.5 nTPM
classical monocyte: 8 nTPM
myeloid DC: 7.6 nTPM

Brain region

choroid plexus: 31 nTPM
cerebellum: 25 nTPM
white matter: 24 nTPM
medulla oblongata: 22 nTPM
hypothalamus: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 3.96
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATAD2B as an antibody target. Whether an autoantibody or antibody against ATAD2B could matter depends on whether native ATAD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATAD2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATAD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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