ABCA10

Protein identityUniProt · HPA

UniProt accession

Q8WWZ4

Gene

ABCA10

Ensembl

ENSG00000154263

Chromosome

17

Canonical length

1543 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1543 residues, UniProt reviewed canonical sequence.

>Q8WWZ4|ABCA10
     1  MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF NWGYRIPVIK
    61  EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII EVTTNHSVME ELTSVIGINM
   121  KIPPFISKGE IMNEWFHFTC LVSFSSFIYF ASLNVARERG KFKKLMTVMG LRESAFWLSW
   181  GLTYICFIFI MSIFMALVIT SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML
   241  AGLAGFLFTV FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP
   301  DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS SFWSKHQNTH
   361  HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY NGKTGKVEAL QGIFFDIYEG
   421  QITAILGHNG AGKSTLLNIL SGLSVSTEGS ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ
   481  FDFLTVRENL RVFAKIKGIQ PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI
   541  AILGDPQVLL LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS
   601  NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT TESEEKLVYS
   661  LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN LEGKSAIDEP DFDIGKQEKI
   721  HVTRNTGDES EMEQVLCSLP ETRKAVSSAA LWRRQIYAVA TLRFLKLRRE RRALLCLLLV
   781  LGIAFIPIIL EKIMYKVTRE THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV
   841  HSLKCQDIVL EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV
   901  SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI GMSSISDYKK
   961  NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY FIFLGFQLSW ELMFVLVVCI
  1021  IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF GFFIILICVS TIMVSTQYEK LNLILCMIFI
  1081  PSFTLLGYVM LLIQLDFMRN LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY
  1141  GNEIMNKDPV FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC
  1201  LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK MITGCTKPTA
  1261  GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE HLELYAAVKG LGKEDAALSI
  1321  SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ
  1381  ILQATVKNKE RGTLLTTHYM SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK
  1441  MKEPTQVEAL HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE
  1501  EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

15

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

15 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.97

gnomAD pLI

0

gnomAD missense Z

-0.06

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• lipid transport

Molecular functions

• ABC-type transporter activity
• ATP binding
• ATP hydrolysis activity
• ATPase-coupled transmembrane transporter activity
• lipid transporter activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• ABC transporter-like, ATP-binding domain
• AAA+ ATPase domain
• ABC-2 type transporter, transmembrane domain
• ABC transporter-like, conserved site
• ABC transporter A
• P-loop containing nucleoside triphosphate hydrolase
• ABCA1-4-like, C-terminal R2 regulatory domain
• ABC transporter
• ABC-2 family transporter protein
• ABCA1-like, C-terminal R1 regulatory domain

KeywordsUniProt

• ATP-binding
• Membrane
• Nucleotide-binding
• Repeat
• Translocase
• Transmembrane
• Transmembrane helix
• Transport