Seroatlas · Human Serome Atlas

ABCE1

ATP-binding cassette sub-family E member 1

Also known as: ABCE1_HUMAN, OABP, RLI, RLI1, RNASEL1, RNASELI, RNS4I

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61221
Gene: ABCE1
Ensembl: ENSG00000164163
Chromosome: 4
Canonical length: 599 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>P61221|ABCE1
     1  MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI
    61  CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL
   121  KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA
   181  KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF
   241  DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT
   301  MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF
   361  ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS
   421  TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA
   481  DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS
   541  KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

tonsil: 39 nTPM
lymph node: 38 nTPM
urinary bladder: 38 nTPM
liver: 37 nTPM
esophagus: 33 nTPM
thymus: 32 nTPM

Single-cell type

erythrocyte progenitors: 137 nCPM
differentiating spermatogonia: 109 nCPM
pancreatic acinar cells: 104 nCPM
megakaryocyte progenitors: 97 nCPM
esophageal basal cells: 93 nCPM
megakaryocyte-erythroid progenitors: 87 nCPM

Immune cell

MAIT T-cell: 26 nTPM
naive CD4 T-cell: 21 nTPM
myeloid DC: 20 nTPM
T-reg: 19 nTPM
naive CD8 T-cell: 18 nTPM
NK-cell: 16 nTPM

Brain region

white matter: 35 nTPM
pons: 28 nTPM
hypothalamus: 28 nTPM
spinal cord: 27 nTPM
cerebellum: 27 nTPM
cerebral cortex: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
gnomAD missense Z: 4.1
DepMap mean gene effect: -2.17
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of translation
rescue of stalled ribosome
ribosome disassembly
translational initiation
translational termination
negative regulation of endoribonuclease activity

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABCE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCE1 as an antibody target. Whether an autoantibody or antibody against ABCE1 could matter depends on whether native ABCE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABCE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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