Seroatlas · Human Serome Atlas

SMARCA1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

Also known as: hSNF2L, ISWI, NURF140, SMCA1_HUMAN, SNF2L, SNF2L1, SNF2LB, SWI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28370
Gene
SMARCA1
Ensembl
ENSG00000102038
Chromosome
X
Canonical length
1042 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

1042 residues, UniProt reviewed canonical sequence.

>P28370|SMARCA1
     1  MEQDTAAVAA TVAAADATAT IVVIEDEQPG PSTSQEEGAA AAATEATAAT EKGEKKKEKN
    61  VSSFQLKLAA KAPKSEKEMD PEYEEKMKAD RAKRFEFLLK QTELFAHFIQ PSAQKSPTSP
   121  LNMKLGRPRI KKDEKQSLIS AGDYRHRRTE QEEDEELLSE SRKTSNVCIR FEVSPSYVKG
   181  GPLRDYQIRG LNWLISLYEN GVNGILADEM GLGKTLQTIA LLGYLKHYRN IPGPHMVLVP
   241  KSTLHNWMNE FKRWVPSLRV ICFVGDKDAR AAFIRDEMMP GEWDVCVTSY EMVIKEKSVF
   301  KKFHWRYLVI DEAHRIKNEK SKLSEIVREF KSTNRLLLTG TPLQNNLHEL WALLNFLLPD
   361  VFNSADDFDS WFDTKNCLGD QKLVERLHAV LKPFLLRRIK TDVEKSLPPK KEIKIYLGLS
   421  KMQREWYTKI LMKDIDVLNS SGKMDKMRLL NILMQLRKCC NHPYLFDGAE PGPPYTTDEH
   481  IVSNSGKMVV LDKLLAKLKE QGSRVLIFSQ MTRLLDILED YCMWRGYEYC RLDGQTPHEE
   541  REEAIEAFNA PNSSKFIFML STRAGGLGIN LASADVVILY DSDWNPQVDL QAMDRAHRIG
   601  QKKPVRVFRL ITDNTVEERI VERAEIKLRL DSIVIQQGRL IDQQSNKLAK EEMLQMIRHG
   661  ATHVFASKES ELTDEDITTI LERGEKKTAE MNERLQKMGE SSLRNFRMDI EQSLYKFEGE
   721  DYREKQKLGM VEWIEPPKRE RKANYAVDAY FREALRVSEP KIPKAPRPPK QPNVQDFQFF
   781  PPRLFELLEK EILYYRKTIG YKVPRNPDIP NPALAQREEQ KKIDGAEPLT PEETEEKEKL
   841  LTQGFTNWTK RDFNQFIKAN EKYGRDDIDN IAREVEGKSP EEVMEYSAVF WERCNELQDI
   901  EKIMAQIERG EARIQRRISI KKALDAKIAR YKAPFHQLRI QYGTSKGKNY TEEEDRFLIC
   961  MLHKMGFDRE NVYEELRQCV RNAPQFRFDW FIKSRTAMEF QRRCNTLISL IEKENMEIEE
  1021  RERAEKKKRA TKTPMVKFSA FS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMARCA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 74 nTPM
  • liver: 58 nTPM
  • testis: 54 nTPM
  • ovary: 53 nTPM
  • thyroid gland: 42 nTPM
  • parathyroid gland: 42 nTPM

Single-cell type

  • sertoli cells: 488 nCPM
  • leydig cells: 241 nCPM
  • choroid plexus epithelial cells: 228 nCPM
  • ovarian stromal cells: 223 nCPM
  • peritubular myoid cells: 191 nCPM
  • pituitary stem cells: 190 nCPM

Immune cell

  • naive CD4 T-cell: 1.1 nTPM
  • NK-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • hypothalamus: 68 nTPM
  • pons: 45 nTPM
  • hippocampal formation: 43 nTPM
  • midbrain: 42 nTPM
  • thalamus: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SMARCA1.

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 392 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
2.44
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMARCA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMARCA1 as an antibody target. Whether an autoantibody or antibody against SMARCA1 could matter depends on whether native SMARCA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMARCA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMARCA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMARCA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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