RASL12
Ras-like protein family member 12
Also known as: RASLC_HUMAN, RIS
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYN1
- Gene
- RASL12
- Ensembl
- ENSG00000103710
- Chromosome
- 15
- Canonical length
- 266 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
266 residues, UniProt reviewed canonical sequence.
>Q9NYN1|RASL12
1 MSSVFGKPRA GSGPQSAPLE VNLAILGRRG AGKSALTVKF LTKRFISEYD PNLEDTYSSE
61 ETVDHQPVHL RVMDTADLDT PRNCERYLNW AHAFLVVYSV DSRQSFDSSS SYLELLALHA
121 KETQRSIPAL LLGNKLDMAQ YRQVTKAEGV ALAGRFGCLF FEVSACLDFE HVQHVFHEAV
181 REARRELEKS PLTRPLFISE ERALPHQAPL TARHGLASCT FNTLSTINLK EMPTVAQAKL
241 VTVKSSRAQS KRKAPTLTLL KGFKIFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RASL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 274 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 274 nTPM
- seminal vesicle: 72 nTPM
- fallopian tube: 65 nTPM
- endometrium: 62 nTPM
- heart muscle: 54 nTPM
- cervix: 54 nTPM
Single-cell type
- smooth muscle cells: 171 nCPM
- vascular smooth muscle cells: 121 nCPM
- retinal pigment epithelial cells: 94 nCPM
- peritubular myoid cells: 69 nCPM
- astrocytes: 64 nCPM
- pericytes: 60 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- thalamus: 131 nTPM
- midbrain: 111 nTPM
- medulla oblongata: 71 nTPM
- spinal cord: 70 nTPM
- hypothalamus: 68 nTPM
- pons: 66 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.63
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RASL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RASL12 as an antibody target. Whether an autoantibody or antibody against RASL12 could matter depends on whether native RASL12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RASL12 is annotated at the cell surface, where native RASL12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RASL12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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