Seroatlas · Human Serome Atlas

RRAGD

Ras-related GTP-binding protein D

Also known as: bA11D8.2.1, DKFZP761H171, RRAGD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQL2
Gene
RRAGD
Ensembl
ENSG00000025039
Chromosome
6
Canonical length
400 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Centrosome

OverviewNCBI Gene

RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9NQL2|RRAGD
     1  MSQVLGKPQP QDEDDAEEEE EEDELVGLAD YGDGPDSSDA DPDSGTEEGV LDFSDPFSTE
    61  VKPRILLMGL RRSGKSSIQK VVFHKMSPNE TLFLESTNKI CREDVSNSSF VNFQIWDFPG
   121  QIDFFDPTFD YEMIFRGTGA LIFVIDSQDD YMEALARLHL TVTRAYKVNT DINFEVFIHK
   181  VDGLSDDHKI ETQRDIHQRA NDDLADAGLE KIHLSFYLTS IYDHSIFEAF SKVVQKLIPQ
   241  LPTLENLLNI FISNSGIEKA FLFDVVSKIY IATDSTPVDM QTYELCCDMI DVVIDISCIY
   301  GLKEDGAGTP YDKESTAIIK LNNTTVLYLK EVTKFLALVC FVREESFERK GLIDYNFHCF
   361  RKAIHEVFEV RMKVVKSRKV QNRLQKKKRA TPNGTPRVLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRAGD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 79 nTPM
  • tongue: 56 nTPM
  • salivary gland: 49 nTPM
  • heart muscle: 36 nTPM
  • thyroid gland: 26 nTPM
  • kidney: 25 nTPM

Single-cell type

  • salivary duct cells: 254 nCPM
  • salivary acinar cells: 250 nCPM
  • esophageal apical cells: 209 nCPM
  • esophageal suprabasal cells: 178 nCPM
  • neutrophil progenitors: 165 nCPM
  • neutrophils: 165 nCPM

Immune cell

  • neutrophil: 3.3 nTPM
  • basophil: 2.7 nTPM
  • non-classical monocyte: 2.4 nTPM
  • eosinophil: 1.4 nTPM
  • classical monocyte: 0.6 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • cerebellum: 65 nTPM
  • white matter: 48 nTPM
  • spinal cord: 45 nTPM
  • basal ganglia: 38 nTPM
  • choroid plexus: 37 nTPM
  • medulla oblongata: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRAGD.

Disease | AllUniProt

Conditions RRAGD is implicated in, by any mechanism.

  • Hypomagnesemia 7, renal, with or without dilated cardiomyopathy (HOMG7) MIM:620152

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypomagnesemia 7, renal, with or without dilated cardiomyopathy
  • HYPOMAGNESEMIA 7, RENAL, WITH DILATED CARDIOMYOPATHY
  • HYPOMAGNESEMIA 7, RENAL, WITHOUT DILATED CARDIOMYOPATHY
  • RRAGD-related disorder
  • Renal tubulopathies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.82
gnomAD missense Z
2.2
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRAGD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRAGD as an antibody target. Whether an autoantibody or antibody against RRAGD could matter depends on whether native RRAGD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRAGD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRAGD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RRAGD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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