Seroatlas · Human Serome Atlas

GTPBP10

GTP-binding protein 10

Also known as: DKFZP686A10121, FLJ38242, GTPBA_HUMAN, OBGH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1E9
Gene: GTPBP10
Ensembl: ENSG00000105793
Chromosome: 7
Canonical length: 387 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>A4D1E9|GTPBP10
     1  MVHCSCVLFR KYGNFIDKLR LFTRGGSGGM GYPRLGGEGG KGGDVWVVAQ NRMTLKQLKD
    61  RYPRKRFVAG VGANSKISAL KGSKGKDCEI PVPVGISVTD ENGKIIGELN KENDRILVAQ
   121  GGLGGKLLTN FLPLKGQKRI IHLDLKLIAD VGLVGFPNAG KSSLLSCVSH AKPAIADYAF
   181  TTLKPELGKI MYSDFKQISV ADLPGLIEGA HMNKGMGHKF LKHIERTRQL LFVVDISGFQ
   241  LSSHTQYRTA FETIILLTKE LELYKEELQT KPALLAVNKM DLPDAQDKFH ELMSQLQNPK
   301  DFLHLFEKNM IPERTVEFQH IIPISAVTGE GIEELKNCIR KSLDEQANQE NDALHKKQLL
   361  NLWISDTMSS TEPPSKHAVT TSKMDII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GTPBP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
thymus: 12 nTPM
kidney: 12 nTPM
skeletal muscle: 11 nTPM
testis: 11 nTPM
lymph node: 10 nTPM

Single-cell type

early spermatids: 135 nCPM
late primary spermatocytes: 76 nCPM
oocytes: 65 nCPM
somatotrophs: 62 nCPM
myonuclei: 60 nCPM
adipocytes: 59 nCPM

Immune cell

basophil: 24 nTPM
T-reg: 13 nTPM
memory B-cell: 12 nTPM
MAIT T-cell: 11 nTPM
naive CD4 T-cell: 11 nTPM
naive CD8 T-cell: 10 nTPM

Brain region

cerebellum: 17 nTPM
hypothalamus: 16 nTPM
white matter: 15 nTPM
pons: 15 nTPM
spinal cord: 15 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial large ribosomal subunit assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GTPBP10 as an antibody target. Whether an autoantibody or antibody against GTPBP10 could matter depends on whether native GTPBP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GTPBP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GTPBP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...