Seroatlas · Human Serome Atlas

ARL4A

ADP-ribosylation factor-like protein 4A

Also known as: ARL4, ARL4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40617
Gene: ARL4A
Ensembl: ENSG00000122644
Chromosome: 7
Canonical length: 200 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>P40617|ARL4A
     1  MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK
    61  VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR
   121  ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE
   181  KLHDMIIKRR KMLRQQKKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

testis: 181 nTPM
bone marrow: 93 nTPM
skin: 85 nTPM
salivary gland: 82 nTPM
vagina: 63 nTPM
small intestine: 59 nTPM

Single-cell type

late spermatids: 6,442 nCPM
late primary spermatocytes: 1,592 nCPM
early spermatids: 1,325 nCPM
breast lactating cells: 1,048 nCPM
enterocytes: 541 nCPM
syncytiotrophoblasts: 490 nCPM

Immune cell

naive B-cell: 45 nTPM
memory B-cell: 41 nTPM
non-classical monocyte: 32 nTPM
MAIT T-cell: 32 nTPM
memory CD4 T-cell: 27 nTPM
intermediate monocyte: 26 nTPM

Brain region

cerebral cortex: 34 nTPM
choroid plexus: 30 nTPM
basal ganglia: 24 nTPM
white matter: 21 nTPM
amygdala: 18 nTPM
hippocampal formation: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.81
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL4A as an antibody target. Whether an autoantibody or antibody against ARL4A could matter depends on whether native ARL4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL4A is annotated at the cell surface, where native ARL4A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARL4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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