Seroatlas · Human Serome Atlas

SWSAP1

ATPase SWSAP1

Also known as: C19orf39, FLJ35119, SWAP1_HUMAN, SWS1AP1, ZSWIM7AP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NVH7
Gene: SWSAP1
Ensembl: ENSG00000173928
Chromosome: 19
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables ATP hydrolysis activity and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q6NVH7|SWSAP1
     1  MPAAGPPLLL LGTPGSGKTA LLFAAALEAA GEGQGPVLFL TRRPLQSMPR GTGTTLDPMR
    61  LQKIRFQYPP STRELFRLLC SAHEAPGPAP SLLLLDGLEE YLAEDPEPQE AAYLIALLLD
   121  TAAHFSHRLG PGRDCGLMVA LQTQEEAGSG DVLHLALLQR YFPAQCWLQP DAPGPGEHGL
   181  RACLEPGGLG PRTEWWVTFR SDGEMMIAPW PTQAGDPSSG KGSSSGGQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SWSAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

liver: 9.9 nTPM
spleen: 9.4 nTPM
lymph node: 6.7 nTPM
adrenal gland: 6.3 nTPM
kidney: 6.3 nTPM
testis: 6 nTPM

Single-cell type

syncytiotrophoblasts: 32 nCPM
adrenal cortex cells: 25 nCPM
cytotrophoblasts: 22 nCPM
epididymal principal cells: 20 nCPM
undifferentiated spermatogonia: 16 nCPM
migrating cytotrophoblasts: 15 nCPM

Immune cell

classical monocyte: 32 nTPM
intermediate monocyte: 31 nTPM
non-classical monocyte: 30 nTPM
myeloid DC: 24 nTPM
memory B-cell: 21 nTPM
neutrophil: 20 nTPM

Brain region

cerebellum: 11 nTPM
choroid plexus: 9 nTPM
white matter: 8.3 nTPM
cerebral cortex: 7.8 nTPM
pons: 7.4 nTPM
medulla oblongata: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SWSAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SWSAP1 as an antibody target. Whether an autoantibody or antibody against SWSAP1 could matter depends on whether native SWSAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SWSAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SWSAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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