NLRC3

Protein identityUniProt · HPA

UniProt accession

Q7RTR2

Gene

NLRC3

Ensembl

ENSG00000167984

Chromosome

16

Canonical length

1065 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

1065 residues, UniProt reviewed canonical sequence.

>Q7RTR2|NLRC3
     1  MRKQEVRTGR EAGQGHGTGS PAEQVKALMD LLAGKGSQGS QAPQALDRTP DAPLGPCSND
    61  SRIQRHRKAL LSKVGGGPEL GGPWHRLASL LLVEGLTDLQ LREHDFTQVE ATRGGGHPAR
   121  TVALDRLFLP LSRVSVPPRV SITIGVAGMG KTTLVRHFVR LWAHGQVGKD FSLVLPLTFR
   181  DLNTHEKLCA DRLICSVFPH VGEPSLAVAV PARALLILDG LDECRTPLDF SNTVACTDPK
   241  KEIPVDHLIT NIIRGNLFPE VSIWITSRPS ASGQIPGGLV DRMTEIRGFN EEEIKVCLEQ
   301  MFPEDQALLG WMLSQVQADR ALYLMCTVPA FCRLTGMALG HLWRSRTGPQ DAELWPPRTL
   361  CELYSWYFRM ALSGEGQEKG KASPRIEQVA HGGRKMVGTL GRLAFHGLLK KKYVFYEQDM
   421  KAFGVDLALL QGAPCSCFLQ REETLASSVA YCFTHLSLQE FVAAAYYYGA SRRAIFDLFT
   481  ESGVSWPRLG FLTHFRSAAQ RAMQAEDGRL DVFLRFLSGL LSPRVNALLA GSLLAQGEHQ
   541  AYRTQVAELL QGCLRPDAAV CARAINVLHC LHELQHTELA RSVEEAMESG ALARLTGPAH
   601  RAALAYLLQV SDACAQEANL SLSLSQGVLQ SLLPQLLYCR KLRLDTNQFQ DPVMELLGSV
   661  LSGKDCRIQK ISLAENQISN KGAKALARSL LVNRSLTSLD LRGNSIGPQG AKALADALKI
   721  NRTLTSLSLQ GNTVRDDGAR SMAEALASNR TLSMLHLQKN SIGPMGAQRM ADALKQNRSL
   781  KELMFSSNSI GDGGAKALAE ALKVNQGLES LDLQSNSISD AGVAALMGAL CTNQTLLSLS
   841  LRENSISPEG AQAIAHALCA NSTLKNLDLT ANLLHDQGAR AIAVAVRENR TLTSLHLQWN
   901  FIQAGAAQAL GQALQLNRSL TSLDLQENAI GDDGACAVAR ALKVNTALTA LYLQVASIGA
   961  SGAQVLGEAL AVNRTLEILD LRGNAIGVAG AKALANALKV NSSLRRLNLQ ENSLGMDGAI
  1021  CIATALSGNH RLQHINLQGN HIGDSGARMI SEAIKTNAPT CTVEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

13 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.24

gnomAD pLI

0

gnomAD missense Z

-0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• canonical NF-kappaB signal transduction
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of cytokine production involved in inflammatory response
• negative regulation of epithelial cell proliferation
• negative regulation of fibroblast proliferation
• negative regulation of inflammatory response
• negative regulation of innate immune response
• negative regulation of interferon-alpha production
• negative regulation of interferon-beta production
• negative regulation of interleukin-6 production
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of NLRP3 inflammasome complex assembly
• negative regulation of non-canonical NF-kappaB signal transduction
• negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• negative regulation of tumor necrosis factor production
• T cell activation

Molecular functions

• ATP binding
• phosphatidylinositol 3-kinase regulatory subunit binding

Cellular components

• centriolar satellite
• cytoplasm
• cytosol
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• NACHT nucleoside triphosphatase
• P-loop containing nucleoside triphosphate hydrolase
• Leucine-rich repeat domain superfamily
• NOD1/2, winged helix domain
• NACHT, LRR and PYD domains-containing protein, helical domain HD2
• NOD-like receptor
• NACHT domain
• Leucine Rich repeat
• NLRC4 helical domain HD2
• NOD2 winged helix domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Leucine-rich repeat
• Nucleotide-binding
• Repeat

InteractionsUniProt · HPA

Protein binding partners of NLRC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASP1
• CASP5
• TRAF6