Seroatlas · Human Serome Atlas

KIF3C

Kinesin-like protein KIF3C

Also known as: KIF3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14782
Gene
KIF3C
Ensembl
ENSG00000084731
Chromosome
2
Canonical length
793 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

793 residues, UniProt reviewed canonical sequence.

>O14782|KIF3C
     1  MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF
    61  DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI
   121  PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL
   181  SSFVTKNVKE IEHVMNLGNQ TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG
   241  KLNLVDLAGS ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL
   301  GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD ESLSTLRFAN
   361  RAKNIKNKPR VNEDPKDTLL REFQEEIARL KAQLEKRGML GKRPRRKSSR RKKAVSAPPG
   421  YPEGPVIEAW VAEEEDDNNN NHRPPQPILE SALEKNMENY LQEQKERLEE EKAAIQDDRS
   481  LVSEEKQKLL EEKEKMLEDL RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE
   541  LKRQEIAEQK RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA
   601  EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL FLDCEEEQWK
   661  FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS HPRYRAENIM FLELDVSPPA
   721  VFEMEFSHDQ EQDPRALHME RLMRLDSFLE RPSTSKVRKS RSWCQSPQRP PPSTTHASLA
   781  SASLRPATVA DHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 76 nTPM
  • cerebellum: 47 nTPM
  • hippocampal formation: 45 nTPM
  • amygdala: 45 nTPM
  • basal ganglia: 42 nTPM
  • hypothalamus: 38 nTPM

Single-cell type

  • retinal ganglion cells: 243 nCPM
  • retinal horizontal cells: 90 nCPM
  • brain excitatory neurons: 72 nCPM
  • other brain neurons: 68 nCPM
  • brain inhibitory neurons: 63 nCPM
  • oligodendrocyte progenitor cells: 56 nCPM

Immune cell

  • neutrophil: 0.5 nTPM
  • T-reg: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM

Brain region

  • cerebral cortex: 257 nTPM
  • pons: 181 nTPM
  • white matter: 178 nTPM
  • hippocampal formation: 178 nTPM
  • basal ganglia: 168 nTPM
  • amygdala: 149 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.36
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF3C as an antibody target. Whether an autoantibody or antibody against KIF3C could matter depends on whether native KIF3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF3C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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