NAV2

Protein identityUniProt · HPA

UniProt accession

Q8IVL1

Gene

NAV2

Ensembl

ENSG00000166833

Chromosome

11

Canonical length

2488 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

2488 residues, UniProt reviewed canonical sequence.

>Q8IVL1|NAV2
     1  MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT TYPSQIPLKS
    61  QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA KSGHKRLIRD LQQDVTDGVL
   121  LAQIIQVVAN EKIEDINGCP KNRSQMIENI DACLNFLAAK GINIQGLSAE EIRNGNLKAI
   181  LGLFFSLSRY KQQQQQPQKQ HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH
   241  QPAPHQQSKA QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG
   301  STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA PASLESGSSS
   361  TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK PPGPEAPRPT PEAMKPAPNN
   421  QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC ERLETLPSFE ESEELEAASR MLTTVGPASS
   481  SPKIALKGIA QRTFSRALTN KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK
   541  EEPKEDPSGA AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP
   601  SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT TLNHSISSQT
   661  VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY RSQTDTEGNV TAESSSTGVS
   721  VEPSHFTKTG QPALEELTGE DPEARRLRTV KNIADLRQNL EETMSSLRGT QVTHSTLETT
   781  FDTNVTTEMS GRSILSLTGR PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE
   841  SGRYVYSAPL RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD
   901  DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS SSVSSGISDT
   961  IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ VERNSLWSGD DVKKSDGGSD
  1021  SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK NPVISQTGSW RRGMTAQVGI TMPRTKPSAP
  1081  AGALKTPGTG KTDDAKVSEK GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA
  1141  NSFGFKKQSG SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD
  1201  GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV PKLREPSKTA
  1261  LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV SSPAQTSLQP GAKYPDVASP
  1321  TLRRLFGGKP TKQVPIATAE NMKNSVVISN PHATMTQQGN LDSPSGSGVL SSGSSSPLYS
  1381  KNVDLNQSPL ASSPSSAHSA PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS
  1441  LSSGGVPSHN SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ
  1501  DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP FSSGSSVTSP
  1561  SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD PYTDSRFRNS SMSLDEKSRT
  1621  MSRSGSFRDG FEEESWEKSS VDNFVSRLHS SLHFSLPLFH HARYELVHGS SLSLVSSTSS
  1681  VYSTPEEKCQ SEIRKLRREL DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM
  1741  TAEQKDSELN ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS
  1801  DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK SASSHSDIEE
  1861  MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE AETVMQLRNE LRDKEMKLTD
  1921  IRLEALSSAH QLDQLREAMN RMQSEIEKLK AENDRLKSES QGSGCSRAPS QVSISASPRQ
  1981  SMGLSQHSLN LTESTSLDML LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI
  2041  GCIGVSGKTK WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE
  2101  LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH RRIILSGPSG
  2161  TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL RQYLSNLADQ CNSENNAVDM
  2221  PLVIILDNLH HVSSLGEIFN GLLNCKYHKC PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN
  2281  HTEPVKGFLG RFLRRKLMET EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG
  2341  PRLFLSCPID VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW
  2401  AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM LMRLQEAANY
  2461  SSPQSYDSDS NSNSHHDDIL DSSLESTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAV2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

57 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.39

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cerebellar cortex development
• locomotory behavior
• nervous system development
• neurogenesis
• optic nerve development
• sensory perception of smell
• sensory perception of sound
• glossopharyngeal nerve development
• regulation of systemic arterial blood pressure by baroreceptor feedback
• vagus nerve development

Molecular functions

• 3'-5' DNA helicase activity
• ATP binding
• ATP hydrolysis activity
• heparin binding

Cellular components

• interstitial matrix
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Calponin homology domain
• AAA+ ATPase domain
• P-loop containing nucleoside triphosphate hydrolase
• CH domain superfamily
• Nav/unc-53 family
• Neuron navigator 1-like, ubiquitin-like domain
• CortBP2/NAV1-like, AAA+ ATPase lid domain
• Calponin homology (CH) domain
• Neuron navigator 1-like, ubiquitin-like domain
• NAV1-like, AAA+ ATPase lid domain

KeywordsUniProt

• ATP-binding
• Cell projection
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Helicase
• Hydrolase
• Nucleotide-binding
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of NAV2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ING5
• PIAS2
• YWHAE
• YWHAZ