Seroatlas · Human Serome Atlas

RAC3

Ras-related C3 botulinum toxin substrate 3

Also known as: RAC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60763
Gene
RAC3
Ensembl
ENSG00000169750
Chromosome
17
Canonical length
192 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P60763|RAC3
     1  MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG
    61  QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR
   121  DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP
   181  PVKKPGKKCT VF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 68 nTPM
  • hypothalamus: 40 nTPM
  • cerebral cortex: 34 nTPM
  • testis: 29 nTPM
  • amygdala: 28 nTPM
  • midbrain: 25 nTPM

Single-cell type

  • extravillous trophoblasts: 216 nCPM
  • undifferentiated spermatogonia: 85 nCPM
  • migrating cytotrophoblasts: 46 nCPM
  • epididymal principal cells: 45 nCPM
  • cytotrophoblasts: 36 nCPM
  • differentiating spermatogonia: 34 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • pons: 47 nTPM
  • hypothalamus: 44 nTPM
  • cerebellum: 44 nTPM
  • midbrain: 37 nTPM
  • basal ganglia: 36 nTPM
  • thalamus: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAC3.

Disease | AllUniProt

Conditions RAC3 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (NEDBAF) MIM:618577

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
1.46
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAC3 as an antibody target. Whether an autoantibody or antibody against RAC3 could matter depends on whether native RAC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAC3 is annotated at the cell surface, where native RAC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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