Seroatlas · Human Serome Atlas

AK6

Adenylate kinase isoenzyme 6

Also known as: CINAP, KAD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3D8
Gene: AK6
Ensembl: ENSG00000085231
Chromosome: 5
Canonical length: 172 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Centrosome
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q9Y3D8|AK6
     1  MLLPNILLTG TPGVGKTTLG KELASKSGLK YINVGDLARE EQLYDGYDEE YDCPILDEDR
    61  VVDELDNQMR EGGVIVDYHG CDFFPERWFH IVFVLRTDTN VLYERLETRG YNEKKLTDNI
   121  QCEIFQVLYE EATASYKEEI VHQLPSNKPE ELENNVDQIL KWIEQWIKDH NS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 77 nTPM
adrenal gland: 55 nTPM
cerebral cortex: 47 nTPM
basal ganglia: 47 nTPM
amygdala: 46 nTPM
heart muscle: 46 nTPM

Single-cell type

late spermatids: 380 nCPM
early spermatids: 159 nCPM
late primary spermatocytes: 33 nCPM
bergmann glia: 22 nCPM
oligodendrocytes: 22 nCPM
other brain neurons: 21 nCPM

Immune cell

plasmacytoid DC: 30 nTPM
memory B-cell: 29 nTPM
naive CD8 T-cell: 26 nTPM
naive B-cell: 26 nTPM
T-reg: 25 nTPM
basophil: 25 nTPM

Brain region

cerebral cortex: 18 nTPM
cerebellum: 17 nTPM
white matter: 17 nTPM
midbrain: 17 nTPM
hypothalamus: 16 nTPM
hippocampal formation: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -1.1
DepMap dependency class: common

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
AAA domain
Adenylate kinase isoenzyme 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COIL

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AK6 as an antibody target. Whether an autoantibody or antibody against AK6 could matter depends on whether native AK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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