Seroatlas · Human Serome Atlas

PARPBP

PCNA-interacting partner

Also known as: C12orf48, FLJ20641, PARI, PARI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWS1
Gene: PARPBP
Ensembl: ENSG00000185480
Chromosome: 12
Canonical length: 579 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q9NWS1|PARPBP
     1  MAVFNQKSVS DMIKEFRKNW RALCNSERTT LCGADSMLLA LQLSMAENNK QHSGEFTVSL
    61  SDVLLTWKYL LHEKLNLPVE NMDVTDHYED VRKIYDDFLK NSNMLDLIDV YQKCRALTSN
   121  CENYNTVSPS QLLDFLSGKQ YAVGDETDLS IPTSPTSKYN RDNEKVQLLA RKIIFSYLNL
   181  LVNSKNDLAV AYILNIPDRG LGREAFTDLK HAAREKQMSI FLVATSFIRT IELGGKGYAP
   241  PPSDPLRTHV KGLSNFINFI DKLDEILGEI PNPSIAGGQI LSVIKMQLIK GQNSRDPFCK
   301  AIEEVAQDLD LRIKNIINSQ EGVVALSTTD ISPARPKSHA INHGTAYCGR DTVKALLVLL
   361  DEEAANAPTK NKAELLYDEE NTIHHHGTSI LTLFRSPTQV NNSIKPLRER ICVSMQEKKI
   421  KMKQTLIRSQ FACTYKDDYM ISKDNWNNVN LASKPLCVLY MENDLSEGVN PSVGRSTIGT
   481  SFGNVHLDRS KNEKVSRKST SQTGNKSSKR KQVDLDGENI LCDNRNEPPQ HKNAKIPKKS
   541  NDSQNRLYGK LAKVAKSNKC TAKDKLISGQ AKLTQFFRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARPBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 8.8 nTPM
thymus: 7 nTPM
tonsil: 4.8 nTPM
lymph node: 3.9 nTPM
testis: 3.7 nTPM
rectum: 3.6 nTPM

Single-cell type

erythrocyte progenitors: 116 nCPM
monocyte progenitors: 101 nCPM
megakaryocyte progenitors: 80 nCPM
neutrophil progenitors: 72 nCPM
differentiating spermatogonia: 54 nCPM
enteric transient amplifying cells: 40 nCPM

Immune cell

basophil: 2.6 nTPM
T-reg: 1.8 nTPM
memory B-cell: 1.1 nTPM
eosinophil: 1 nTPM
memory CD4 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

hypothalamus: 1.1 nTPM
pons: 1.1 nTPM
cerebellum: 0.9 nTPM
cerebral cortex: 0.9 nTPM
spinal cord: 0.9 nTPM
medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
PCNA-interacting partner

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARPBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARPBP as an antibody target. Whether an autoantibody or antibody against PARPBP could matter depends on whether native PARPBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARPBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARPBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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