Seroatlas · Human Serome Atlas

DLG2

Disks large homolog 2

Also known as: chapsyn-110, DLG2_HUMAN, PPP1R58, PSD-93, PSD93

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15700
Gene
DLG2
Ensembl
ENSG00000150672
Chromosome
11
Canonical length
870 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>Q15700|DLG2
     1  MFFACYCALR TNVKKYRYQD EDAPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL
    61  QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH
   121  IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY
   181  VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ
   241  VGDRLLMVNN YSLEEVTHEE AVAILKNTSE VVYLKVGKPT TIYMTDPYGP PDITHSYSPP
   301  MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLVDDDY TRPPEPVYST VNKLCDKPAS
   361  PRHYSPVECD KSFLLSAPYS HYHLGLLPDS EMTSHSQHST ATRQPSMTLQ RAVSLEGEPR
   421  KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH
   481  EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY
   541  VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVMLEGDS EEMGVIPSKR
   601  RVERKERARL KTVKFNAKPG VIDSKGSFND KRKKSFIFSR KFPFYKNKEQ SEQETSDPER
   661  GQEDLILSYE PVTRQEINYT RPVIILGPMK DRINDDLISE FPDKFGSCVP HTTRPKRDYE
   721  VDGRDYHFVI SREQMEKDIQ EHKFIEAGQY NDNLYGTSVQ SVRFVAERGK HCILDVSGNA
   781  IKRLQVAQLY PIAIFIKPRS LEPLMEMNKR LTEEQAKKTY DRAIKLEQEF GEYFTAIVQG
   841  DTLEDIYNQC KLVIEEQSGP FIWIPSKEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 47 nTPM
  • hippocampal formation: 45 nTPM
  • amygdala: 38 nTPM
  • basal ganglia: 34 nTPM
  • spinal cord: 31 nTPM
  • hypothalamus: 23 nTPM

Single-cell type

  • retinal bipolar cells: 12,776 nCPM
  • cone photoreceptor cells: 6,564 nCPM
  • oligodendrocytes: 4,673 nCPM
  • pituicytes/fscs: 4,338 nCPM
  • brain excitatory neurons: 3,712 nCPM
  • brain inhibitory neurons: 3,587 nCPM

Immune cell

  • naive B-cell: 0.7 nTPM
  • MAIT T-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • eosinophil: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM

Brain region

  • white matter: 222 nTPM
  • hippocampal formation: 193 nTPM
  • cerebral cortex: 187 nTPM
  • basal ganglia: 172 nTPM
  • amygdala: 137 nTPM
  • hypothalamus: 132 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DLG2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.71
gnomAD missense Z
2.08
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLG2 as an antibody target. Whether an autoantibody or antibody against DLG2 could matter depends on whether native DLG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLG2 is annotated at the cell surface, where native DLG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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