Seroatlas · Human Serome Atlas

WSCD1

Sialate:O-sulfotransferase 1

Also known as: KIAA0523, WSCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q658N2
Gene: WSCD1
Ensembl: ENSG00000179314
Chromosome: 17
Canonical length: 575 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable sulfotransferase activity. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q658N2|WSCD1
     1  MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRVRV ALPQGPRAPG PLQTLPVAAV
    61  ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR WLRSRNSELR QLRRRWFHHF
   121  MSDSQGPPAL GPEAARPAIH SRGTYIGCFS DDGHERTLKG AVFYDLRKMT VSHCQDACAE
   181  RSYVYAGLEA GAECYCGNRL PAVSVGLEEC NHECKGEKGS VCGAVDRLSV YRVDELQPGS
   241  RKRRTATYRG CFRLPENITH AFPSSLIQAN VTVGTCSGFC SQKEFPLAIL RGWECYCAYP
   301  TPRFNLRDAM DSSVCGQDPE AQRLAEYCEV YQTPVQDTRC TDRRFLPNKS KVFVALSSFP
   361  GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW RSRRTICVKT HESGRREIEM
   421  FDSAILLIRN PYRSLVAEFN RKCAGHLGYA ADRNWKSKEW PDFVNSYASW WSSHVLDWLK
   481  YGKRLLVVHY EELRRSLVPT LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP
   541  FTPEMKDLIN GYIRTVDQAL RDHNWTGLPR EYVPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WSCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
cerebral cortex: 16 nTPM
spinal cord: 15 nTPM
midbrain: 14 nTPM
amygdala: 13 nTPM
hippocampal formation: 13 nTPM

Single-cell type

late spermatids: 172 nCPM
oligodendrocyte progenitor cells: 168 nCPM
early spermatids: 162 nCPM
bergmann glia: 62 nCPM
lactotrophs: 52 nCPM
retinal bipolar cells: 50 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 51 nTPM
medulla oblongata: 50 nTPM
white matter: 44 nTPM
pons: 42 nTPM
midbrain: 39 nTPM
thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

sulfotransferase activity

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WSCD1 as an antibody target. Whether an autoantibody or antibody against WSCD1 could matter depends on whether native WSCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WSCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WSCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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