Seroatlas · Human Serome Atlas

KIF2A

Kinesin-like protein KIF2A

Also known as: HK2, KIF2, KIF2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00139
Gene
KIF2A
Ensembl
ENSG00000068796
Chromosome
5
Canonical length
706 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Mitotic spindle,Centrosome,Basal body,Cytosol,Mid piece,Principal piece,Annulus

OverviewNCBI Gene

The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>O00139|KIF2A
     1  MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF
    61  SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP
   121  SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL
   181  REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM
   241  KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET
   301  IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL
   361  QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC
   421  RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE
   481  INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT
   541  LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE
   601  EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA
   661  TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • testis: 46 nTPM
  • thymus: 41 nTPM
  • retina: 40 nTPM
  • cerebral cortex: 35 nTPM
  • lymph node: 31 nTPM
  • tonsil: 27 nTPM

Single-cell type

  • platelets: 1,557 nCPM
  • megakaryocytes: 457 nCPM
  • megakaryocyte progenitors: 226 nCPM
  • late spermatids: 162 nCPM
  • fallopian tube ciliated cells: 126 nCPM
  • late primary spermatocytes: 114 nCPM

Immune cell

  • T-reg: 43 nTPM
  • MAIT T-cell: 35 nTPM
  • memory CD8 T-cell: 33 nTPM
  • memory CD4 T-cell: 30 nTPM
  • gdT-cell: 29 nTPM
  • naive CD8 T-cell: 29 nTPM

Brain region

  • white matter: 90 nTPM
  • hypothalamus: 81 nTPM
  • basal ganglia: 75 nTPM
  • pons: 73 nTPM
  • midbrain: 72 nTPM
  • medulla oblongata: 72 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF2A.

Disease | AllUniProt

Conditions KIF2A is implicated in, by any mechanism.

  • Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3) MIM:615411

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 652 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
4.04
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF2A as an antibody target. Whether an autoantibody or antibody against KIF2A could matter depends on whether native KIF2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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