Seroatlas · Human Serome Atlas

KIF1B

Kinesin-like protein KIF1B

Also known as: CMT2, CMT2A, HMSNII, KIAA0591, KIF1B_HUMAN, KLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60333
Gene: KIF1B
Ensembl: ENSG00000054523
Chromosome: 1
Canonical length: 1816 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Microtubules,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Enables plus-end-directed microtubule motor activity. Involved in apoptotic process involved in development and mitochondrion transport along microtubule. Is active in mitochondrion. Implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1816 residues, UniProt reviewed canonical sequence.

>O60333|KIF1B
     1  MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
    61  SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
   121  QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED
   181  LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK
   241  VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
   301  TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIKCNAVI
   361  NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD YSGSGSKYLK DFQNNKHRYL
   421  LASENQRPGH FSTASMGSLT SSPSSCSLSS QVGLTSVTSI QERIMSTPGG EEAIERLKES
   481  EKIIAELNET WEEKLRKTEA IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED
   541  PLMSECLLYY IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC
   601  ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA ETPSEPVDWT
   661  FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL EQQRLDYESK LQALQKQVET
   721  RSLAAETTEE EEEEEEVPWT QHEFELAQWA FRKWKSHQFT SLRDLLWGNA VYLKEANAIS
   781  VELKKKVQFQ FVLLTDTLYS PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW
   841  SLEKLKQRLD LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV
   901  NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE EGSDLFSDGH
   961  DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG EVRGFLRVAV QAIAADEEAP
  1021  DYGSGIRQSG TAKISFDNEY FNQSDFSSVA MTRSGLSLEE LRIVEGQGQS SEVITPPEEI
  1081  SRINDLDLKS STLLDGKMVM EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF
  1141  NFLHRHDEAF STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH
  1201  PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY DLLVWFEISE
  1261  LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH EKGSELHWKD VRELVVGRIR
  1321  NKPEVDEAAV DAILSLNIIS AKYLKSSHNS SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK
  1381  IYMTLSAYLE LDHCIQPAVI TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG
  1441  IYELSLCKMS DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE
  1501  LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS TTTFESAITP
  1561  SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV HGSVSDCKLS DISPIGRDPS
  1621  ESSFSSATLT PSSTCPSLVD SRSNSLDQKT PEANSRASSP CPEFEQFQIV PAVETPYLAR
  1681  AGKNEFLNLV PDIEEIRPSS VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV
  1741  ERGIINLSTA QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG
  1801  TIRSKLSRRC PSQSKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 185 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 185 nTPM
tongue: 142 nTPM
retina: 119 nTPM
cerebellum: 74 nTPM
amygdala: 70 nTPM
cerebral cortex: 70 nTPM

Single-cell type

neutrophils: 1,944 nCPM
rod photoreceptor cells: 1,477 nCPM
myonuclei: 1,338 nCPM
cone photoreceptor cells: 1,153 nCPM
neutrophil progenitors: 896 nCPM
astrocytes: 844 nCPM

Immune cell

neutrophil: 8 nTPM
eosinophil: 6.2 nTPM
basophil: 3.4 nTPM
non-classical monocyte: 1.7 nTPM
classical monocyte: 1.6 nTPM
T-reg: 1.3 nTPM

Brain region

white matter: 347 nTPM
pons: 301 nTPM
basal ganglia: 288 nTPM
amygdala: 272 nTPM
cerebellum: 271 nTPM
midbrain: 269 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF1B.

Disease | AllUniProt

Conditions KIF1B is implicated in, by any mechanism.

Charcot-Marie-Tooth disease, axonal, type 2A1 (CMT2A1) MIM:118210
Neuroblastoma 1 (NBLST1) MIM:256700
Pheochromocytoma (PCC) MIM:171300

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 4,050 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Charcot-Marie-Tooth disease type 2A1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.6
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF1B as an antibody target. Whether an autoantibody or antibody against KIF1B could matter depends on whether native KIF1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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