Seroatlas · Human Serome Atlas

ARL3

ADP-ribosylation factor-like protein 3

Also known as: ARFL3, ARL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36405
Gene
ARL3
Ensembl
ENSG00000138175
Chromosome
10
Canonical length
182 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

Enables GDP binding activity; GTP binding activity; and microtubule binding activity. Involved in several processes, including cilium assembly; protein localization to cilium; and small GTPase-mediated signal transduction. Acts upstream of or within post-Golgi vesicle-mediated transport. Located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Implicated in Joubert syndrome and retinitis pigmentosa 83. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>P36405|ARL3
     1  MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG
    61  FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP
   121  VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK
   181  KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • retina: 89 nTPM
  • basal ganglia: 32 nTPM
  • cerebral cortex: 30 nTPM
  • choroid plexus: 28 nTPM
  • amygdala: 27 nTPM
  • cerebellum: 25 nTPM

Single-cell type

  • fallopian tube ciliated cells: 403 nCPM
  • rod photoreceptor cells: 382 nCPM
  • respiratory ciliated cells: 306 nCPM
  • epididymal efferent duct ciliated cells: 280 nCPM
  • endometrial ciliated cells: 268 nCPM
  • late primary spermatocytes: 256 nCPM

Immune cell

  • neutrophil: 13 nTPM
  • MAIT T-cell: 9.4 nTPM
  • classical monocyte: 7.2 nTPM
  • myeloid DC: 7.1 nTPM
  • memory CD4 T-cell: 6.5 nTPM
  • intermediate monocyte: 6.2 nTPM

Brain region

  • cerebral cortex: 33 nTPM
  • basal ganglia: 28 nTPM
  • cerebellum: 27 nTPM
  • hypothalamus: 27 nTPM
  • thalamus: 26 nTPM
  • pons: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARL3.

Disease | AllUniProt

Conditions ARL3 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Joubert syndrome 35
  • Progressive cone degeneration
  • Retinitis pigmentosa 83

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
1.16
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL3 as an antibody target. Whether an autoantibody or antibody against ARL3 could matter depends on whether native ARL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...