DDX27

Protein identityUniProt · HPA

UniProt accession

Q96GQ7

Gene

DDX27

Canonical length

765 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for DDX27 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q96GQ7|DDX27
     1  MLADLGLIGT IGEDDEVPVE PESDSGDEEE EGPIVLGRRQ KALGKNRSAD FNPDFVFTEK
    61  EGTYDGSWAL ADVMSQLKKK RAATTLDEKI EKVRKKRKTE DKEAKSGKLE KEKEAKEGSE
   121  PKEQEDLQEN DEEGSEDEAS ETDYSSADEN ILTKADTLKV KDRKKKKKKG QEAGGFFEDA
   181  SQYDENLSFQ DMNLSRPLLK AITAMGFKQP TPIQKACIPV GLLGKDICAC AATGTGKTAA
   241  FALPVLERLI YKPRQAPVTR VLVLVPTREL GIQVHSVTRQ LAQFCNITTC LAVGGLDVKS
   301  QEAALRAAPD ILIATPGRLI DHLHNCPSFH LSSIEVLILD EADRMLDEYF EEQMKEIIRM
   361  CSHHRQTMLF SATMTDEVKD LASVSLKNPV RIFVNSNTDV APFLRQEFIR IRPNREGDRE
   421  AIVAALLTRT FTDHVMLFTQ TKKQAHRMHI LLGLMGLQVG ELHGNLSQTQ RLEALRRFKD
   481  EQIDILVATD VAARGLDIEG VKTVINFTMP NTIKHYVHRV GRTARAGRAG RSVSLVGEDE
   541  RKMLKEIVKA AKAPVKARIL PQDVILKFRD KIEKMEKDVY AVLQLEAEEK EMQQSEAQIN
   601  TAKRLLEKGK EAVVQEPERS WFQTKEERKK EKIAKALQEF DLALRGKKKR KKFMKDAKKK
   661  GEMTAEERSQ FEILKAQMFA ERLAKRNRRA KRARAMPEEE PVRGPAKKQK QGKKSVFDEE
   721  LTNTSKKALK QYRAGPSFEE RKQLGLPHQR RGGNFKSKSR YKRRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

44 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DDX27.

Disease | AutoantibodyPubMed

Conditions in which antibodies against DDX27 are reported. Each links to that disease's full target list.

Showing 0 of 1 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for DDX27 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.58

gnomAD missense Z

1.73

DepMap mean gene effect

-1.06

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• rRNA processing

Molecular functions

• ATP binding
• ATP hydrolysis activity
• RNA binding
• RNA helicase activity

Cellular components

• chromosome
• nucleolus

Protein domainsUniProt · Pfam · InterPro

• ATP-dependent RNA helicase DEAD-box, conserved site
• Helicase, C-terminal domain-like
• DEAD/DEAH-box helicase domain
• Helicase superfamily 1/2, ATP-binding domain
• RNA helicase, DEAD-box type, Q motif
• P-loop containing nucleoside triphosphate hydrolase
• DEAD box RNA helicase
• DEAD/DEAH box helicase
• Helicase conserved C-terminal domain

KeywordsUniProt

• ATP-binding
• Chromosome
• Helicase
• Hydrolase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Ribosome biogenesis
• rRNA processing

InteractionsUniProt · HPA

Protein binding partners of DDX27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BOP1
• PES1
• NPM1
• WDR12