Seroatlas · Human Serome Atlas

MPP7

MAGUK p55 subfamily member 7

Also known as: FLJ32798, MPP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T2T1
Gene
MPP7
Ensembl
ENSG00000150054
Chromosome
10
Canonical length
576 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q5T2T1|MPP7
     1  MPALSTGSGS DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL VKIHEKLHYY
    61  EKQSPVPILH GAAALADDLA EELQNKPLNS EIRELLKLLS KPNVKALLSV HDTVAQKNYD
   121  PVLPPMPEDI DDEEDSVKII RLVKNREPLG ATIKKDEQTG AIIVARIMRG GAADRSGLIH
   181  VGDELREVNG IPVEDKRPEE IIQILAQSQG AITFKIIPGS KEETPSKEGK MFIKALFDYN
   241  PNEDKAIPCK EAGLSFKKGD ILQIMSQDDA TWWQAKHEAD ANPRAGLIPS KHFQERRLAL
   301  RRPEILVQPL KVSNRKSSGF RKSFRLSRKD KKTNKSMYEC KKSDQYDTAD VPTYEEVTPY
   361  RRQTNEKYRL VVLVGPVGVG LNELKRKLLI SDTQHYGVTV PHTTRARRSQ ESDGVEYIFI
   421  SKHLFETDVQ NNKFIEYGEY KNNYYGTSID SVRSVLAKNK VCLLDVQPHT VKHLRTLEFK
   481  PYVIFIKPPS IERLRETRKN AKIISSRDDQ GAAKPFTEED FQEMIKSAQI MESQYGHLFD
   541  KIIINDDLTV AFNELKTTFD KLETETHWVP VSWLHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 35 nTPM
  • skin: 24 nTPM
  • thyroid gland: 13 nTPM
  • tongue: 13 nTPM
  • skeletal muscle: 13 nTPM
  • kidney: 12 nTPM

Single-cell type

  • neutrophil progenitors: 656 nCPM
  • neutrophils: 610 nCPM
  • lymphatic endothelial cells: 424 nCPM
  • renal collecting duct intercalated cells: 408 nCPM
  • cytotrophoblasts: 381 nCPM
  • esophageal apical cells: 289 nCPM

Immune cell

  • eosinophil: 13 nTPM
  • myeloid DC: 12 nTPM
  • naive CD4 T-cell: 12 nTPM
  • classical monocyte: 11 nTPM
  • naive CD8 T-cell: 8.8 nTPM
  • NK-cell: 8.7 nTPM

Brain region

  • cerebellum: 18 nTPM
  • cerebral cortex: 12 nTPM
  • white matter: 7.3 nTPM
  • basal ganglia: 7 nTPM
  • hypothalamus: 5.7 nTPM
  • amygdala: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.9
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPP7 as an antibody target. Whether an autoantibody or antibody against MPP7 could matter depends on whether native MPP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPP7 is annotated at the cell surface, where native MPP7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MPP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MPP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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