Seroatlas · Human Serome Atlas

DSEL

Dermatan-sulfate epimerase-like protein

Also known as: C18orf4, DE-epi2, DSEL_HUMAN, FLJ11477, NCAG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZU8
Gene: DSEL
Ensembl: ENSG00000171451
Chromosome: 18
Canonical length: 1212 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable chondroitin-glucuronate 5-epimerase activity. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1212 residues, UniProt reviewed canonical sequence.

>Q8IZU8|DSEL
     1  MALMFTGHLL FLALLMFAFS TFEESVSNYS EWAVFTDDID QFKTQKVQDF RPNQKLKKSM
    61  LHPSLYFDAG EIQAMRQKSR ASHLHLFRAI RSAVTVMLSN PTYYLPPPKH ADFAAKWNEI
   121  YGNNLPPLAL YCLLCPEDKV AFEFVLEYMD RMVGYKDWLV ENAPGDEVPI GHSLTGFATA
   181  FDFLYNLLDN HRRQKYLEKI WVITEEMYEY SKVRSWGKQL LHNHQATNMI ALLTGALVTG
   241  VDKGSKANIW KQAVVDVMEK TMFLLNHIVD GSLDEGVAYG SYTAKSVTQY VFLAQRHFNI
   301  NNLDNNWLKM HFWFYYATLL PGFQRTVGIA DSNYNWFYGP ESQLVFLDKF ILKNGAGNWL
   361  AQQIRKHRPK DGPMVPSTAQ RWSTLHTEYI WYDPQLTPQP PADYGTAKIH TFPNWGVVTY
   421  GAGLPNTQTN TFVSFKSGKL GGRAVYDIVH FQPYSWIDGW RSFNPGHEHP DQNSFTFAPN
   481  GQVFVSEALY GPKLSHLNNV LVFAPSPSSQ CNKPWEGQLG ECAQWLKWTG EEVGDAAGEI
   541  ITASQHGEMV FVSGEAVSAY SSAMRLKSVY RALLLLNSQT LLVVDHIERQ EDSPINSVSA
   601  FFHNLDIDFK YIPYKFMNRY NGAMMDVWDA HYKMFWFDHH GNSPMASIQE AEQAAEFKKR
   661  WTQFVNVTFQ MEPTITRIAY VFYGPYINVS SCRFIDSSNP GLQISLNVNN TEHVVSIVTD
   721  YHNLKTRFNY LGFGGFASVA DQGQITRFGL GTQAIVKPVR HDRIIFPFGF KFNIAVGLIL
   781  CISLVILTFQ WRFYLSFRKL MRWILILVIA LWFIELLDVW STCSQPICAK WTRTEAEGSK
   841  KSLSSEGHHM DLPDVVITSL PGSGAEILKQ LFFNSSDFLY IRVPTAYIDI PETELEIDSF
   901  VDACEWKVSD IRSGHFRLLR GWLQSLVQDT KLHLQNIHLH EPNRGKLAQY FAMNKDKKRK
   961  FKRRESLPEQ RSQMKGAFDR DAEYIRALRR HLVYYPSARP VLSLSSGSWT LKLHFFQEVL
  1021  GASMRALYIV RDPRAWIYSM LYNSKPSLYS LKNVPEHLAK LFKIEGGKGK CNLNSGYAFE
  1081  YEPLRKELSK SKSNAVSLLS HLWLANTAAA LRINTDLLPT SYQLVKFEDI VHFPQKTTER
  1141  IFAFLGIPLS PASLNQILFA TSTNLFYLPY EGEISPTNTN VWKQNLPRDE IKLIENICWT
  1201  LMDRLGYPKF MD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 6.2 nTPM
placenta: 5.8 nTPM
cerebral cortex: 5.7 nTPM
cervix: 4.7 nTPM
spinal cord: 4.7 nTPM
kidney: 4 nTPM

Single-cell type

oligodendrocyte progenitor cells: 156 nCPM
oligodendrocytes: 107 nCPM
brain inhibitory neurons: 55 nCPM
other brain neurons: 38 nCPM
brain excitatory neurons: 27 nCPM
proximal tubule cells: 15 nCPM

Immune cell

basophil: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 22 nTPM
pons: 20 nTPM
basal ganglia: 20 nTPM
midbrain: 18 nTPM
cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.06
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSEL as an antibody target. Whether an autoantibody or antibody against DSEL could matter depends on whether native DSEL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSEL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSEL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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