Seroatlas · Human Serome Atlas

DIRAS1

GTP-binding protein Di-Ras1

Also known as: Di-Ras1, DIRA1_HUMAN, GBTS1, RIG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95057
Gene: DIRAS1
Ensembl: ENSG00000176490
Chromosome: 19
Canonical length: 198 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O95057|DIRAS1
     1  MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT
    61  DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG
   121  NKCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK
   181  RSGKQKRTDR VKGKCTLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIRAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 99 nTPM
cerebral cortex: 90 nTPM
tongue: 48 nTPM
cerebellum: 47 nTPM
hippocampal formation: 34 nTPM
amygdala: 31 nTPM

Single-cell type

retinal horizontal cells: 38 nCPM
retinal amacrine cells: 33 nCPM
brain excitatory neurons: 21 nCPM
brain inhibitory neurons: 20 nCPM
other brain neurons: 14 nCPM
gonadotrophs: 13 nCPM

Immune cell

memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 240 nTPM
thalamus: 160 nTPM
white matter: 135 nTPM
pons: 101 nTPM
hypothalamus: 100 nTPM
cerebellum: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.39
gnomAD missense Z: 2.07
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIRAS1 as an antibody target. Whether an autoantibody or antibody against DIRAS1 could matter depends on whether native DIRAS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIRAS1 is annotated at the cell surface, where native DIRAS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DIRAS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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