RAB36
Ras-related protein Rab-36
Also known as: RAB36_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95755
- Gene
- RAB36
- Ensembl
- ENSG00000100228
- Chromosome
- 22
- Canonical length
- 267 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
267 residues, UniProt reviewed canonical sequence.
>O95755|RAB36
1 MRSSLTPLGP PVSRDRVIAS FPKWYTPEAC LQLREHFHGQ VSAACQRRNT GTVGLKLSKV
61 VVVGDLYVGK TSLIHRFCKN VFDRDYKATI GVDFEIERFE IAGIPYSLQI WDTAGQEKFK
121 CIASAYYRGA QVIITAFDLT DVQTLEHTRQ WLEDALRENE AGSCFIFLVG TKKDLLSGAA
181 CEQAEADAVH LAREMQAEYW SVSAKTGENV KAFFSRVAAL AFEQSVLQDL ERQSSARLQV
241 GNGDLIQMEG SPPETQESKR PSSLGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 26 nTPM
- thyroid gland: 14 nTPM
- pituitary gland: 14 nTPM
- choroid plexus: 13 nTPM
- kidney: 7.8 nTPM
- cerebral cortex: 7.4 nTPM
Single-cell type
- respiratory ciliated cells: 142 nCPM
- fallopian tube ciliated cells: 80 nCPM
- endometrial ciliated cells: 61 nCPM
- respiratory deuterosomal cells: 50 nCPM
- epididymal efferent duct ciliated cells: 46 nCPM
- late spermatids: 39 nCPM
Immune cell
- neutrophil: 11 nTPM
- NK-cell: 1.4 nTPM
- memory B-cell: 0.7 nTPM
- classical monocyte: 0.5 nTPM
- gdT-cell: 0.4 nTPM
- MAIT T-cell: 0.3 nTPM
Brain region
- choroid plexus: 47 nTPM
- midbrain: 26 nTPM
- hypothalamus: 22 nTPM
- hippocampal formation: 22 nTPM
- medulla oblongata: 22 nTPM
- basal ganglia: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB36 as an antibody target. Whether an autoantibody or antibody against RAB36 could matter depends on whether native RAB36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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