RASD2

Protein identityUniProt · HPA

UniProt accession

Q96D21

Gene

RASD2

Ensembl

ENSG00000100302

Chromosome

22

Canonical length

266 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q96D21|RASD2
     1  MMKTLSSGNC TLSVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY
    61  NIRGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DNRESFDEVK RLQKQILEVK
   121  SCLKNKTKEA AELPMVICGN KNDHGELCRQ VPTTEAELLV SGDENCAYFE VSAKKNTNVD
   181  EMFYVLFSMA KLPHEMSPAL HRKISVQYGD AFHPRPFCMR RVKEMDAYGM VSPFARRPSV
   241  NSDLKYIKAK VLREGQARER DKCTIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

184 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0.54

gnomAD missense Z

1.69

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• locomotory behavior
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of protein sumoylation
• signal transduction
• synaptic transmission, dopaminergic

Molecular functions

• G-protein beta-subunit binding
• GTP binding
• GTPase activity

Cellular components

• plasma membrane
• synapse

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Small GTPase RasD
• Ras family

KeywordsUniProt

• Cell membrane
• GTP-binding
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Prenylation

InteractionsUniProt · HPA

Protein binding partners of RASD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GNB1
• GNB2
• GNB3
• HTT
• PIK3CA
• UBE2I