TPST1
Protein-tyrosine sulfotransferase 1
Also known as: TANGO13A, TPST1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60507
- Gene
- TPST1
- Ensembl
- ENSG00000169902
- Chromosome
- 7
- Canonical length
- 370 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Golgi apparatus
- Secretome location
- Intracellular and membrane
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in post-translational protein modification. Located in Golgi membrane. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
370 residues, UniProt reviewed canonical sequence.
>O60507|TPST1
1 MVGKLKQNLL LACLVISSVT VFYLGQHAME CHHRIEERSQ PVKLESTRTT VRTGLDLKAN
61 KTFAYHKDMP LIFIGGVPRS GTTLMRAMLD AHPDIRCGEE TRVIPRILAL KQMWSRSSKE
121 KIRLDEAGVT DEVLDSAMQA FLLEIIVKHG EPAPYLCNKD PFALKSLTYL SRLFPNAKFL
181 LMVRDGRASV HSMISRKVTI AGFDLNSYRD CLTKWNRAIE TMYNQCMEVG YKKCMLVHYE
241 QLVLHPERWM RTLLKFLQIP WNHSVLHHEE MIGKAGGVSL SKVERSTDQV IKPVNVGALS
301 KWVGKIPPDV LQDMAVIAPM LAKLGYDPYA NPPNYGKPDP KIIENTRRVY KGEFQLPDFL
361 KEKPQTEQVELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TPST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- liver: 47 nTPM
- urinary bladder: 38 nTPM
- gallbladder: 36 nTPM
- cervix: 33 nTPM
- hypothalamus: 29 nTPM
- placenta: 25 nTPM
Single-cell type
- neutrophils: 2,758 nCPM
- endometrial stromal cells: 618 nCPM
- smooth muscle cells: 469 nCPM
- decidual stromal cells: 412 nCPM
- early primary spermatocytes: 393 nCPM
- renal connecting tubule cells: 391 nCPM
Immune cell
- basophil: 53 nTPM
- neutrophil: 35 nTPM
- eosinophil: 24 nTPM
- naive B-cell: 14 nTPM
- NK-cell: 8.9 nTPM
- memory B-cell: 6.2 nTPM
Brain region
- medulla oblongata: 74 nTPM
- hypothalamus: 72 nTPM
- midbrain: 48 nTPM
- pons: 46 nTPM
- spinal cord: 43 nTPM
- amygdala: 41 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.54
- gnomAD pLI
- 0.29
- gnomAD missense Z
- 1.36
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TPST1 as an antibody target. Whether an autoantibody or antibody against TPST1 could matter depends on whether native TPST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TPST1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TPST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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