Seroatlas · Human Serome Atlas

TOR4A

Torsin-4A

Also known as: C9orf167, FLJ20245, TOR4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXH8
Gene: TOR4A
Ensembl: ENSG00000198113
Chromosome: 9
Canonical length: 423 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in endoplasmic reticulum lumen and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9NXH8|TOR4A
     1  MDRGQPSLEP AAAAPRASGR CVIAPVRAVL RLRRRVCVLR KRRLLQPGGG PDVGTGAPRP
    61  GCSPRAPRAD LDQPKFFTFD SPAELPSRTP RKKRRRSRLV LYPETSRKYR PRVEHRSRAQ
   121  RCLLLLVAIV GFQVLNAIEN LDDNAQRYDL DGLEKALQRA VFGQPAAVSR IVALMRDYLA
   181  THVHSRPLLL ALHGPSGVGK SHVGRLLARH FRSVLEDSAL VLQYHARHHC PEARAAQDCR
   241  EELARRVADV VARAEAEEKT PLLVLDDVEL MPRPLLDELH GFLQPQRSHH FHNAIYVLLS
   301  GAGGAEVTRF VLQNASRALP LRPDGFRSAE AAAAQAEEDL RASLLAVLSR EHPLWQAAAI
   361  VPFLLLDKRD VVSCFRDEMA GEGFFPDQAR AENLAAQLSF YRVAGREFAV TGCKQVVATV
   421  NLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOR4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

spleen: 15 nTPM
heart muscle: 12 nTPM
stomach: 12 nTPM
colon: 12 nTPM
lung: 10 nTPM
small intestine: 10 nTPM

Single-cell type

platelets: 37 nCPM
colonocytes: 35 nCPM
enteric transient amplifying cells: 34 nCPM
esophageal apical cells: 31 nCPM
enteric stem cells: 27 nCPM
foveolar cells: 27 nCPM

Immune cell

eosinophil: 1.3 nTPM
non-classical monocyte: 1.2 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.7 nTPM
basophil: 0.5 nTPM
myeloid DC: 0.5 nTPM

Brain region

thalamus: 6.5 nTPM
medulla oblongata: 5.5 nTPM
spinal cord: 5.1 nTPM
pons: 4.9 nTPM
midbrain: 4.4 nTPM
white matter: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.56
gnomAD missense Z: 2.92
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOR4A as an antibody target. Whether an autoantibody or antibody against TOR4A could matter depends on whether native TOR4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOR4A is annotated as secreted, so native TOR4A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TOR4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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