GBP7

Protein identityUniProt · HPA

UniProt accession

Q8N8V2

Gene

GBP7

Ensembl

ENSG00000213512

Chromosome

1

Canonical length

638 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

638 residues, UniProt reviewed canonical sequence.

>Q8N8V2|GBP7
     1  MASEIHMPGP VCLTENTKGH LVVNSEALEI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG
    61  KNKGFPLGCT VKSETKGIWM WCVPHPSKPN HTLILLDTEG LGDMEKSDPK SDSWIFALAV
   121  LLSSSFVYNS MGTINHQALE QLHYVTELTE LIRAKSCPRP DEVEDSSEFV SFFPDFIWTV
   181  RDFTLELKLD GHPITEDEYL ENALKLISGK NPQIQNSNKP REWIRHFFPK QKCFVFDRPI
   241  NDKKLLLHVE EVREDQLDSN FQMQSENFCS YIFTHAKTKT LREGILVTGN RLGMLVETYL
   301  DAINSGATPC LENAMAVLAQ CENSAAVQRA ANHYSQQMAQ QVRFPTDTLQ ELLDVHAVCE
   361  REAIAVFMEY SFKDKSQEFQ KKLVDTMEKK KEDFVLQNEE ASAKYCQAEL KRLSELLTES
   421  ISRGTFFVPG GHNIYLEAKK KIEQDYTLVP RKGVKADEVL QSFLQSQVVI EESILQSDKA
   481  LTAGEKAIAA KQAKKEAAEK EQELLRQKQK EQQQMMEAQE RSFQENIAQL KKKMEREREN
   541  YMRELRKMLS HKMKVLEELL TEGFKEIFES LNEEINRLKE QIEAAENEEP SVFSQILDVA
   601  GSIFIAALPG AAKLVDLGMK ILSSLCNRLR NPGKKIIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

94 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0

gnomAD missense Z

-0.25

DepMap mean gene effect

0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to type II interferon
• cytolysis in another organism
• defense response to bacterium
• defense response to Gram-positive bacterium
• defense response to protozoan
• defense response to virus
• negative regulation of cytokine production
• negative regulation of receptor signaling pathway via JAK-STAT
• negative regulation of type I interferon production
• positive regulation of viral genome replication
• regulation of canonical NF-kappaB signal transduction
• negative regulation of type III interferon production

Molecular functions

• GTP binding
• GTPase activity

Cellular components

• cytoplasmic vesicle
• cytoplasmic vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Guanylate-binding protein/Atlastin, C-terminal
• Guanylate-binding protein, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• GB1/RHD3-type guanine nucleotide-binding (G) domain
• Guanylate-binding protein, C-terminal domain superfamily
• Guanylate-binding protein, C-terminal
• Guanylate-binding protein, N-terminal domain
• Guanylate-binding protein, C-terminal domain

KeywordsUniProt

• Antimicrobial
• Antiviral defense
• Cytoplasmic vesicle
• GTP-binding
• Hydrolase
• Immunity
• Innate immunity
• Membrane
• Nucleotide-binding

InteractionsUniProt · HPA

Protein binding partners of GBP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATG4B
• CYBA
• NCF4
• NCF2
• CYBB