Seroatlas · Human Serome Atlas

RAB40A

Ras-related protein Rab-40A

Also known as: Rar-2, RAR2A, RB40A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXH6
Gene: RAB40A
Ensembl: ENSG00000172476
Chromosome: X
Canonical length: 277 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q8WXH6|RAB40A
     1  MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGAAE SPYSHLGGID YKTTTILLDG
    61  QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP
   121  KILVGNRLHL AFKRQVPREQ AQAYAERLGV TFFEVSPLCN FNIIESFTEL ARIVLLRHRM
   181  NWLGRPSKVL SLQDLCCRTI VSCTPVHLVD KLPLPSTLRS HLKSFSMAKG LNARMMRGLS
   241  YSLTTSSTHK SSLCKVEIVC PPQSPPKNCT RNSCKIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB40A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

epididymis: 7.6 nTPM
esophagus: 6.6 nTPM
endometrium: 4.8 nTPM
ovary: 4.3 nTPM
testis: 3.7 nTPM
prostate: 3.3 nTPM

Single-cell type

epicardial cells: 212 nCPM
sertoli cells: 52 nCPM
epididymal principal cells: 50 nCPM
mesothelial cells: 19 nCPM
schwann cells: 19 nCPM
peritubular myoid cells: 17 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 20 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 9.5 nTPM
cerebral cortex: 8.9 nTPM
hypothalamus: 8.7 nTPM
medulla oblongata: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.79
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB40A as an antibody target. Whether an autoantibody or antibody against RAB40A could matter depends on whether native RAB40A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB40A is annotated at the cell surface, where native RAB40A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB40A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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