Seroatlas · Human Serome Atlas

KIF18A

Kinesin-like protein KIF18A

Also known as: DKFZP434G2226, KI18A_HUMAN, PPP1R99

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI77
Gene: KIF18A
Ensembl: ENSG00000121621
Chromosome: 11
Canonical length: 898 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge

OverviewNCBI Gene

KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

898 residues, UniProt reviewed canonical sequence.

>Q8NI77|KIF18A
     1  MSVTEEDLCH HMKVVVRVRP ENTKEKAAGF HKVVHVVDKH ILVFDPKQEE VSFFHGKKTT
    61  NQNVIKKQNK DLKFVFDAVF DETSTQSEVF EHTTKPILRS FLNGYNCTVL AYGATGAGKT
   121  HTMLGSADEP GVMYLTMLHL YKCMDEIKEE KICSTAVSYL EVYNEQIRDL LVNSGPLAVR
   181  EDTQKGVVVH GLTLHQPKSS EEILHLLDNG NKNRTQHPTD MNATSSRSHA VFQIYLRQQD
   241  KTASINQNVR IAKMSLIDLA GSERASTSGA KGTRFVEGTN INRSLLALGN VINALADSKR
   301  KNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSVFYD DTYNTLKYAN RAKDIKSSLK
   361  SNVLNVNNHI TQYVKICNEQ KAEILLLKEK LKAYEEQKAF TNENDQAKLM ISNPQEKEIE
   421  RFQEILNCLF QNREEIRQEY LKLEMLLKEN ELKSFYQQQC HKQIEMMCSE DKVEKATGKR
   481  DHRLAMLKTR RSYLEKRREE ELKQFDENTN WLHRVEKEMG LLSQNGHIPK ELKKDLHCHH
   541  LHLQNKDLKA QIRHMMDLAC LQEQQHRQTE AVLNALLPTL RKQYCTLKEA GLSNAAFESD
   601  FKEIEHLVER KKVVVWADQT AEQPKQNDLP GISVLMTFPQ LGPVQPIPCC SSSGGTNLVK
   661  IPTEKRTRRK LMPSPLKGQH TLKSPPSQSV QLNDSLSKEL QPIVYTPEDC RKAFQNPSTV
   721  TLMKPSSFTT SFQAISSNIN SDNCLKMLCE VAIPHNRRKE CGQEDLDSTF TICEDIKSSK
   781  CKLPEQESLP NDNKDILQRL DPSSFSTKHS MPVPSMVPSY MAMTTAAKRK RKLTSSTSNS
   841  SLTADVNSGF AKRVRQDNSS EKHLQENKPT MEHKRNICKI NPSMVRKFGR NISKGNLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF18A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
thymus: 8.9 nTPM
bone marrow: 7.8 nTPM
lymph node: 4.3 nTPM
tonsil: 4.3 nTPM
rectum: 1.9 nTPM

Single-cell type

early primary spermatocytes: 95 nCPM
monocyte progenitors: 93 nCPM
late primary spermatocytes: 93 nCPM
megakaryocyte progenitors: 80 nCPM
erythrocyte progenitors: 72 nCPM
neutrophil progenitors: 50 nCPM

Immune cell

basophil: 4.2 nTPM
NK-cell: 1.4 nTPM
T-reg: 1.1 nTPM
memory B-cell: 1 nTPM
memory CD4 T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM

Brain region

thalamus: 0.4 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -1.3
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding
ATP binding
ATP hydrolysis activity
microtubule binding
microtubule plus-end binding
plus-end-directed microtubule motor activity
tubulin-dependent ATPase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF18A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF18A as an antibody target. Whether an autoantibody or antibody against KIF18A could matter depends on whether native KIF18A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF18A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF18A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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