Seroatlas · Human Serome Atlas

NLRP6

NACHT, LRR and PYD domains-containing protein 6

Also known as: CLR11.4, NALP6, NLRP6_HUMAN, PAN3, PYPAF5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P59044
Gene
NLRP6
Ensembl
ENSG00000174885
Chromosome
11
Canonical length
892 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homomultimer

OverviewNCBI Gene

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

892 residues, UniProt reviewed canonical sequence.

>P59044|NLRP6
     1  MDQPEAPCSS TGPRLAVARE LLLAALEELS QEQLKRFRHK LRDVGPDGRS IPWGRLERAD
    61  AVDLAEQLAQ FYGPEPALEV ARKTLKRADA RDVAAQLQER RLQRLGLGSG TLLSVSEYKK
   121  KYREHVLQLH ARVKERNARS VKITKRFTKL LIAPESAAPE EAMGPAEEPE PGRARRSDTH
   181  TFNRLFRRDE EGRRPLTVVL QGPAGIGKTM AAKKILYDWA AGKLYQGQVD FAFFMPCGEL
   241  LERPGTRSLA DLILDQCPDR GAPVPQMLAQ PQRLLFILDG ADELPALGGP EAAPCTDPFE
   301  AASGARVLGG LLSKALLPTA LLLVTTRAAA PGRLQGRLCS PQCAEVRGFS DKDKKKYFYK
   361  YFRDERRAER AYRFVKENET LFALCFVPFV CWIVCTVLRQ QLELGRDLSR TSKTTTSVYL
   421  LFITSVLSSA PVADGPRLQG DLRNLCRLAR EGVLGRRAQF AEKELEQLEL RGSKVQTLFL
   481  SKKELPGVLE TEVTYQFIDQ SFQEFLAALS YLLEDGGVPR TAAGGVGTLL RGDAQPHSHL
   541  VLTTRFLFGL LSAERMRDIE RHFGCMVSER VKQEALRWVQ GQGQGCPGVA PEVTEGAKGL
   601  EDTEEPEEEE EGEEPNYPLE LLYCLYETQE DAFVRQALCR FPELALQRVR FCRMDVAVLS
   661  YCVRCCPAGQ ALRLISCRLV AAQEKKKKSL GKRLQASLGG GSSSQGTTKQ LPASLLHPLF
   721  QAMTDPLCHL SSLTLSHCKL PDAVCRDLSE ALRAAPALTE LGLLHNRLSE AGLRMLSEGL
   781  AWPQCRVQTV RVQLPDPQRG LQYLVGMLRQ SPALTTLDLS GCQLPAPMVT YLCAVLQHQG
   841  CGLQTLSLAS VELSEQSLQE LQAVKRAKPD LVITHPALDG HPQPPKELIS TF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLRP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 38 nTPM
  • duodenum: 38 nTPM
  • spleen: 3.5 nTPM
  • liver: 2.5 nTPM
  • appendix: 2.1 nTPM
  • kidney: 1.3 nTPM

Single-cell type

  • enterocytes: 60 nCPM
  • neutrophils: 56 nCPM
  • enteric transient amplifying cells: 11 nCPM
  • t-cells: 9.2 nCPM
  • innate lymphoid cells: 6.9 nCPM
  • enteric stem cells: 6.3 nCPM

Immune cell

  • neutrophil: 16 nTPM
  • non-classical monocyte: 4.6 nTPM
  • naive CD8 T-cell: 2.3 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • MAIT T-cell: 1.4 nTPM

Brain region

  • cerebral cortex: 8.4 nTPM
  • medulla oblongata: 1.8 nTPM
  • pons: 1.5 nTPM
  • hypothalamus: 1.2 nTPM
  • white matter: 1 nTPM
  • thalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
1.76
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLRP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLRP6 as an antibody target. Whether an autoantibody or antibody against NLRP6 could matter depends on whether native NLRP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLRP6 is annotated at the cell surface, where native NLRP6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NLRP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NLRP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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