Seroatlas · Human Serome Atlas

MTG2

Mitochondrial ribosome-associated GTPase 2

Also known as: dJ1005F21.2, FLJ10741, GTPBP5, MTG2_HUMAN, ObgH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4K7
Gene: MTG2
Ensembl: ENSG00000101181
Chromosome: 20
Canonical length: 406 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9H4K7|MTG2
     1  MAPARCFSAR LRTVFQGVGH WALSTWAGLK PSRLLPQRAS PRLLSVGRAD LAKHQELPGK
    61  KLLSEKKLKR YFVDYRRVLV CGGNGGAGAS CFHSEPRKEF GGPDGGDGGN GGHVILRVDQ
   121  QVKSLSSVLS RYQGFSGEDG GSKNCFGRSG AVLYIRVPVG TLVKEGGRVV ADLSCVGDEY
   181  IAALGGAGGK GNRFFLANNN RAPVTCTPGQ PGQQRVLHLE LKTVAHAGMV GFPNAGKSSL
   241  LRAISNARPA VASYPFTTLK PHVGIVHYEG HLQIAVADIP GIIRGAHQNR GLGSAFLRHI
   301  ERCRFLLFVV DLSQPEPWTQ VDDLKYELEM YEKGLSARPH AIVANKIDLP EAQANLSQLR
   361  DHLGQEVIVL SALTGENLEQ LLLHLKVLYD AYAEAELGQG RQPLRW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 26 nTPM
liver: 22 nTPM
adrenal gland: 14 nTPM
cerebellum: 12 nTPM
pancreas: 11 nTPM
testis: 11 nTPM

Single-cell type

myonuclei: 95 nCPM
late primary spermatocytes: 79 nCPM
adrenal cortex cells: 65 nCPM
differentiating spermatogonia: 58 nCPM
retinal horizontal cells: 56 nCPM
choroid plexus epithelial cells: 54 nCPM

Immune cell

neutrophil: 9.9 nTPM
gdT-cell: 5.1 nTPM
myeloid DC: 4.9 nTPM
basophil: 4.8 nTPM
NK-cell: 4.8 nTPM
intermediate monocyte: 4.3 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 9.4 nTPM
thalamus: 9 nTPM
hypothalamus: 8.9 nTPM
basal ganglia: 8.8 nTPM
medulla oblongata: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTG2 as an antibody target. Whether an autoantibody or antibody against MTG2 could matter depends on whether native MTG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...