Seroatlas · Human Serome Atlas

CHST1

Carbohydrate sulfotransferase 1

Also known as: C6ST, CHST1_HUMAN, KSGal6ST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43916
Gene
CHST1
Ensembl
ENSG00000175264
Chromosome
11
Canonical length
411 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Mitochondria
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>O43916|CHST1
     1  MQCSWKAVLL LALASIAIQY TAIRTFTAKS FHTCPGLAEA GLAERLCEES PTFAYNLSRK
    61  THILILATTR SGSSFVGQLF NQHLDVFYLF EPLYHVQNTL IPRFTQGKSP ADRRVMLGAS
   121  RDLLRSLYDC DLYFLENYIK PPPVNHTTDR IFRRGASRVL CSRPVCDPPG PADLVLEEGD
   181  CVRKCGLLNL TVAAEACRER SHVAIKTVRV PEVNDLRALV EDPRLNLKVI QLVRDPRGIL
   241  ASRSETFRDT YRLWRLWYGT GRKPYNLDVT QLTTVCEDFS NSVSTGLMRP PWLKGKYMLV
   301  RYEDLARNPM KKTEEIYGFL GIPLDSHVAR WIQNNTRGDP TLGKHKYGTV RNSAATAEKW
   361  RFRLSYDIVA FAQNACQQVL AQLGYKIAAS EEELKNPSVS LVEERDFRPF S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHST1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 41 nTPM
  • basal ganglia: 32 nTPM
  • amygdala: 32 nTPM
  • hippocampal formation: 28 nTPM
  • hypothalamus: 22 nTPM
  • midbrain: 19 nTPM

Single-cell type

  • late primary spermatocytes: 211 nCPM
  • lacrimal acinar cells: 67 nCPM
  • early spermatids: 66 nCPM
  • astrocytes: 61 nCPM
  • adrenal medulla cells: 43 nCPM
  • brain excitatory neurons: 26 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 106 nTPM
  • amygdala: 98 nTPM
  • hippocampal formation: 93 nTPM
  • thalamus: 85 nTPM
  • basal ganglia: 84 nTPM
  • hypothalamus: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.77
gnomAD missense Z
2.95
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHST1 as an antibody target. Whether an autoantibody or antibody against CHST1 could matter depends on whether native CHST1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHST1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHST1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHST1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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