Seroatlas · Human Serome Atlas

TOR1B

Torsin-1B

Also known as: DQ1, MGC4386, TOR1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14657
Gene
TOR1B
Ensembl
ENSG00000136816
Chromosome
9
Canonical length
336 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles,Cytosol
Quaternary structure
Homohexamer

OverviewNCBI Gene

The protein encoded by this gene is an ATPase found primarily in the endoplasmic reticulum and nuclear envelope. This gene has a highly-similar neighboring gene, TOR1A, that encodes a protein that is likely to interact in a complex with this protein. Finally, this protein may act as a chaperone and play a role in maintaining the integrity of the nuclear envelope and endoplasmic reticulum. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>O14657|TOR1B
     1  MLRAGWLRGA AALALLLAAR VVAAFEPITV GLAIGAASAI TGYLSYNDIY CRFAECCREE
    61  RPLNASALKL DLEEKLFGQH LATEVIFKAL TGFRNNKNPK KPLTLSLHGW AGTGKNFVSQ
   121  IVAENLHPKG LKSNFVHLFV STLHFPHEQK IKLYQDQLQK WIRGNVSACA NSVFIFDEMD
   181  KLHPGIIDAI KPFLDYYEQV DGVSYRKAIF IFLSNAGGDL ITKTALDFWR AGRKREDIQL
   241  KDLEPVLSVG VFNNKHSGLW HSGLIDKNLI DYFIPFLPLE YRHVKMCVRA EMRARGSAID
   301  EDIVTRVAEE MTFFPRDEKI YSDKGCKTVQ SRLDFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOR1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 21 nTPM
  • colon: 19 nTPM
  • liver: 17 nTPM
  • urinary bladder: 15 nTPM
  • bone marrow: 14 nTPM
  • placenta: 13 nTPM

Single-cell type

  • neutrophils: 78 nCPM
  • neutrophil progenitors: 53 nCPM
  • late primary spermatocytes: 49 nCPM
  • colonocytes: 44 nCPM
  • goblet cells: 44 nCPM
  • retinal horizontal cells: 36 nCPM

Immune cell

  • eosinophil: 20 nTPM
  • neutrophil: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • classical monocyte: 13 nTPM
  • MAIT T-cell: 13 nTPM
  • gdT-cell: 13 nTPM

Brain region

  • cerebellum: 18 nTPM
  • choroid plexus: 13 nTPM
  • hypothalamus: 13 nTPM
  • thalamus: 12 nTPM
  • medulla oblongata: 12 nTPM
  • pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.06
gnomAD missense Z
0.96
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOR1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOR1B as an antibody target. Whether an autoantibody or antibody against TOR1B could matter depends on whether native TOR1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOR1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOR1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOR1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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