Seroatlas · Human Serome Atlas

GPN3

GPN-loop GTPase 3

Also known as: ATPBD1C, GPN3_HUMAN, MGC14560

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHW5
Gene: GPN3
Ensembl: ENSG00000111231
Chromosome: 12
Canonical length: 284 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q9UHW5|GPN3
     1  MPRYAQLVMG PAGSGKSTYC ATMVQHCEAL NRSVQVVNLD PAAEHFNYSV MADIRELIEV
    61  DDVMEDDSLR FGPNGGLVFC MEYFANNFDW LENCLGHVED DYILFDCPGQ IELYTHLPVM
   121  KQLVQQLEQW EFRVCGVFLV DSQFMVESFK FISGILAALS AMISLEIPQV NIMTKMDLLS
   181  KKAKKEIEKF LDPDMYSLLE DSTSDLRSKK FKKLTKAICG LIDDYSMVRF LPYDQSDEES
   241  MNIVLQHIDF AIQYGEDLEF KEPKEREDES SSMFDEYFQE CQDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

tongue: 48 nTPM
skeletal muscle: 45 nTPM
testis: 39 nTPM
heart muscle: 32 nTPM
liver: 30 nTPM
kidney: 29 nTPM

Single-cell type

late primary spermatocytes: 236 nCPM
hofbauer cells: 141 nCPM
early primary spermatocytes: 140 nCPM
oocytes: 111 nCPM
extravillous trophoblasts: 94 nCPM
breast lactating cells: 94 nCPM

Immune cell

eosinophil: 80 nTPM
non-classical monocyte: 76 nTPM
intermediate monocyte: 72 nTPM
plasmacytoid DC: 63 nTPM
classical monocyte: 55 nTPM
myeloid DC: 51 nTPM

Brain region

white matter: 20 nTPM
spinal cord: 15 nTPM
cerebellum: 15 nTPM
medulla oblongata: 15 nTPM
pons: 14 nTPM
choroid plexus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.99
DepMap mean gene effect: -1.23
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein import into nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

GPN-loop GTPase
P-loop containing nucleoside triphosphate hydrolase
Conserved hypothetical ATP binding protein
GPN-loop GTPase 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPN3 as an antibody target. Whether an autoantibody or antibody against GPN3 could matter depends on whether native GPN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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