ARL8A
ADP-ribosylation factor-like protein 8A
Also known as: ARL10B, ARL8A_HUMAN, FLJ45195, Gie2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BM9
- Gene
- ARL8A
- Ensembl
- ENSG00000143862
- Chromosome
- 1
- Canonical length
- 186 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables GTP binding activity. Predicted to be involved in anterograde axonal transport and chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
186 residues, UniProt reviewed canonical sequence.
>Q96BM9|ARL8A
1 MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI
61 TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QEKIEASKNE LHNLLDKPQL
121 QGIPVLVLGN KRDLPGALDE KELIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH
181 SKSRRSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 157 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 157 nTPM
- midbrain: 99 nTPM
- hippocampal formation: 89 nTPM
- hypothalamus: 80 nTPM
- cerebral cortex: 75 nTPM
- basal ganglia: 74 nTPM
Single-cell type
- neutrophils: 202 nCPM
- alveolar cells type 1: 108 nCPM
- oligodendrocytes: 105 nCPM
- kupffer cells: 93 nCPM
- syncytiotrophoblasts: 88 nCPM
- neutrophil progenitors: 85 nCPM
Immune cell
- eosinophil: 7.3 nTPM
- neutrophil: 5.2 nTPM
- basophil: 3.6 nTPM
- plasmacytoid DC: 2.7 nTPM
- classical monocyte: 2.1 nTPM
- intermediate monocyte: 2.1 nTPM
Brain region
- white matter: 175 nTPM
- medulla oblongata: 155 nTPM
- cerebellum: 139 nTPM
- basal ganglia: 138 nTPM
- midbrain: 136 nTPM
- pons: 135 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.35
- gnomAD pLI
- 0.94
- gnomAD missense Z
- 2.92
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ARL8A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL8A as an antibody target. Whether an autoantibody or antibody against ARL8A could matter depends on whether native ARL8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL8A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARL8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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