Seroatlas · Human Serome Atlas

UCK2

Uridine-cytidine kinase 2

Also known as: UCK2_HUMAN, UMPK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZX2
Gene: UCK2
Ensembl: ENSG00000143179
Chromosome: 1
Canonical length: 261 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q9BZX2|UCK2
     1  MAGDSEQTLQ NHQQPNGGEP FLIGVSGGTA SGKSSVCAKI VQLLGQNEVD YRQKQVVILS
    61  QDSFYRVLTS EQKAKALKGQ FNFDHPDAFD NELILKTLKE ITEGKTVQIP VYDFVSHSRK
   121  EETVTVYPAD VVLFEGILAF YSQEVRDLFQ MKLFVDTDAD TRLSRRVLRD ISERGRDLEQ
   181  ILSQYITFVK PAFEEFCLPT KKYADVIIPR GADNLVAINL IVQHIQDILN GGPSKRQTNG
   241  CLNGYTPSRK RQASESSSRP H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

placenta: 26 nTPM
esophagus: 18 nTPM
thymus: 17 nTPM
skeletal muscle: 16 nTPM
pancreas: 15 nTPM
breast: 14 nTPM

Single-cell type

bergmann glia: 161 nCPM
corticotrophs: 127 nCPM
early spermatids: 111 nCPM
extravillous trophoblasts: 111 nCPM
thymocytes: 106 nCPM
salivary acinar cells: 89 nCPM

Immune cell

myeloid DC: 15 nTPM
plasmacytoid DC: 14 nTPM
classical monocyte: 5.9 nTPM
naive B-cell: 4.5 nTPM
non-classical monocyte: 4.2 nTPM
NK-cell: 3.8 nTPM

Brain region

pons: 23 nTPM
midbrain: 21 nTPM
cerebellum: 20 nTPM
medulla oblongata: 19 nTPM
cerebral cortex: 18 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.72
gnomAD missense Z: 2.81
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UCK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UCK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCK2 as an antibody target. Whether an autoantibody or antibody against UCK2 could matter depends on whether native UCK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UCK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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