Seroatlas · Human Serome Atlas

RND1

Rho-related GTP-binding protein Rho6

Also known as: ARHS, Rho6, RHOS, RND1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92730
Gene: RND1
Ensembl: ENSG00000172602
Chromosome: 12
Canonical length: 232 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Actin filaments

OverviewNCBI Gene

This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q92730|RND1
     1  MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR
    61  VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV
   121  LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF
   181  RTASMLCLNK PSPLPQKSPV RSLSKRLLHL PSRSELISST FKKEKAKSCS IM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RND1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

liver: 120 nTPM
cerebral cortex: 49 nTPM
lung: 33 nTPM
amygdala: 23 nTPM
basal ganglia: 23 nTPM
stomach: 22 nTPM

Single-cell type

vascular endothelial cells: 145 nCPM
epididymal efferent duct absorptive cells: 127 nCPM
salivary acinar cells: 88 nCPM
breast hormone-responsive cells: 75 nCPM
alveolar cells type 2: 72 nCPM
transitional alveolar cells: 52 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM
myeloid DC: 0.3 nTPM
naive B-cell: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebral cortex: 31 nTPM
basal ganglia: 26 nTPM
midbrain: 20 nTPM
white matter: 18 nTPM
thalamus: 17 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.74
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RND1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RND1 as an antibody target. Whether an autoantibody or antibody against RND1 could matter depends on whether native RND1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RND1 is annotated at the cell surface, where native RND1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RND1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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