Seroatlas · Human Serome Atlas

NDST2

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

Also known as: HSST2, NDST2_HUMAN, NST2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52849
Gene
NDST2
Ensembl
ENSG00000166507
Chromosome
10
Canonical length
883 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

883 residues, UniProt reviewed canonical sequence.

>P52849|NDST2
     1  MLQLWKVVRP ARQLELHRLI LLLIAFSLGS MGFLAYYVST SPKAKEPLPL PLGDCSSGGA
    61  AGPGPARPPV PPRPPRPPET ARTEPVVLVF VESAYSQLGQ EIVAILESSR FRYSTELAPG
   121  RGDMPTLTDN THGRYVLVIY ENLLKYVNLD AWSRELLDRY CVEYGVGIIG FFRAHEHSLL
   181  SAQLKGFPLF LHSNLGLRDY QVNPSAPLLH LTRPSRLEPG PLPGDDWTIF QSNHSTYEPV
   241  LLASLRPAEP AVPGPVLRRA RLPTVVQDLG LHDGIQRVLF GHGLSFWLHK LIFVDAVAYL
   301  TGKRLCLDLD RYILVDIDDI FVGKEGTRMK VADVEALLTT QNKLRTLVPN FTFNLGFSGK
   361  FYHTGTEEED AGDDMLLKHR KEFWWFPHMW SHMQPHLFHN RSVLADQMRL NKQFALEHGI
   421  PTDLGYAVAP HHSGVYPIHT QLYEAWKSVW GIQVTSTEEY PHLRPARYRR GFIHNGIMVL
   481  PRQTCGLFTH TIFYNEYPGG SRELDRSIRG GELFLTVLLN PISIFMTHLS NYGNDRLGLY
   541  TFESLVRFLQ CWTRLRLQTL PPVPLAQKYF ELFPQERSPL WQNPCDDKRH KDIWSKEKTC
   601  DRLPKFLIVG PQKTGTTAIH FFLSLHPAVT SSFPSPSTFE EIQFFNSPNY HKGIDWYMDF
   661  FPVPSNASTD FLFEKSATYF DSEVVPRRGA ALLPRAKIIT VLTNPADRAY SWYQHQRAHG
   721  DPVALNYTFY QVISASSQTP LALRSLQNRC LVPGYYSTHL QRWLTYYPSG QLLIVDGQEL
   781  RTNPAASMES IQKFLGITPF LNYTRTLRFD DDKGFWCQGL EGGKTRCLGR SKGRRYPDMD
   841  TESRLFLTDF FRNHNLELSK LLSRLGQPVP SWLREELQHS SLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • spleen: 34 nTPM
  • thymus: 30 nTPM
  • lymph node: 23 nTPM
  • tonsil: 22 nTPM
  • cerebellum: 19 nTPM

Single-cell type

  • mast cells: 9 nCPM
  • late spermatids: 5.1 nCPM
  • paneth cells: 3.9 nCPM
  • microglia: 3 nCPM
  • epididymal principal cells: 2.9 nCPM
  • astrocytes: 2.6 nCPM

Immune cell

  • plasmacytoid DC: 3.5 nTPM
  • naive CD8 T-cell: 3.4 nTPM
  • MAIT T-cell: 3.1 nTPM
  • neutrophil: 2.8 nTPM
  • classical monocyte: 2.7 nTPM
  • gdT-cell: 2.7 nTPM

Brain region

  • cerebellum: 28 nTPM
  • cerebral cortex: 23 nTPM
  • medulla oblongata: 22 nTPM
  • thalamus: 22 nTPM
  • hypothalamus: 19 nTPM
  • basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.13
gnomAD missense Z
1.56
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDST2 as an antibody target. Whether an autoantibody or antibody against NDST2 could matter depends on whether native NDST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NDST2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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