HELZ2

Protein identityUniProt · HPA

UniProt accession

Q9BYK8

Gene

HELZ2

Ensembl

ENSG00000130589

Chromosome

20

Canonical length

2896 aa

Protein class

Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

2896 residues, UniProt reviewed canonical sequence.

>Q9BYK8|HELZ2
     1  MAPPGSTLLP NSPAATRGPS LARLCALVDL CLGCSRCTQR LNESTYVLRR VEHDCSREIL
    61  LARFKQATKS KVWRVVGCRP TFPRPLCYQV CHYYSPGLGC RRHRNRCTFA RSREEALVWT
   121  FERQHNLQRL WLKAEVQGSG AQGGAGRAAD AILTEFGGRF ELLCSLCFRR CPPCICRVDP
   181  QGQCPEHGAC PSLLAHVSAE GRRKQQFVVV RPRPRAGQPP AYCRFVGRGQ PCWRGESRCQ
   241  FAHSAVEMAV WEAEQLGGLQ RGDLLTPPAP DGDGRTAPLG QPPGAQLYCP ACLVTCHSQE
   301  AFENHCASSE HAQMVAFDQA LPWEHRSPPP GLSKFELCPK PDLCEYGDAC TKAHSAQELQ
   361  EWVRRTQAVE LRGQAAWQDG LVPYQERLLA EYQRSSSEVL VLAETLDGVR VTCNQPLMYQ
   421  AQERKTQYSW TFAVHSEEPL LHVALLKQEP GADFSLVAPG LPPGRLYARG ERFRVPSSTA
   481  DFQVGVRVQA ASFGTFEQWV VFDFGRRPVL LQKLGLQLGQ GRRPGPCRNL ALGHPEEMER
   541  WHTGNRHVVP GVERTAEQTA LMAKYKGPAL ALEFNRSSVA SGPISPTNYR QRMHQFLYEE
   601  EAAQQQLVAK LTLRGQVFLK TALQTPALNM LFAPPGALYA EVPVPSSLMP DTDQGFLLGR
   661  AVSTALVAPV PAPDNTVFEV RLERRASSEQ ALWLLLPARC CLALGLQPEA RLVLEVQFQI
   721  DPMTFRLWHQ AVDTLPEEQL VVPDLPTCAL PRPWSVPPLR RGNRKQELAV ALIAGWGPGD
   781  GRRVPPLLIY GPFGTGKTYT LAMASLEVIR RPETKVLICT HTNSAADIYI REYFHSHVSG
   841  GHPEATPLRV MYTDRPLSQT DPVTLQYCCL TDDRQAFRPP TRAELARHRV VVTTTSQARE
   901  LRVPVGFFSH ILIDEAAQML ECEALTPLAY ASHGTRLVLA GDHMQVTPRL FSVARARAAE
   961  HTLLHRLFLC YQQETHEVAR QSRLVFHENY RCTDAIVSFI SRHFYVAKGN PIHARGKVPP
  1021  HPRHYPLMFC HVAGSPDRDM SMASWLNLAE IAQVVEKVQE AYNTWPSCWG GREQRCICVV
  1081  SHGAQVSALR QELRRRDLGQ VSVGSFEILP GRQFRVVVLS TVHTCQSLLS PGALAPEFFT
  1141  DARVLNTVLT RAQSQLVVVG DAVALCSFGA CGKLWESFIR ECVERHSVCP EGLSMEQVEQ
  1201  GVAQRRRWPP RGTQAGAAGN WEAAPEPVGD LAEEQAAVVT AMVKAEPGDE ALSPASRDIT
  1261  ATTAQTEAAA APAGDAVKED VVPGACAAGA AAAAGVESTE AEDAEADFWP WDGELNADDA
  1321  ILRELLDESQ KVMVTVGEDG LLDTVARPES LQQARLYENL PPAALRKLLH AEPERYRHCS
  1381  FVPETFERAS AIPLDDASSG PIQVRGRLDC GMAFAGDEVL VQLLSGDKAP EGRLRGRVLG
  1441  VLKRKRHELA FVCRMDTWDP RIMVPINGSV TKIFVAELKD PSQVPIYSLR KGRLQRVGLE
  1501  RLTAEARHSR LFWVQIVLWR QGFYYPLGIV REVLPEASTW EQGLRILGLE YSLRVPPSDQ
  1561  ATITKVLQKY HTELGRVAGR REDCRAFLTF TVDPQGACNL DDALSVRDLG PRCEVAVHIT
  1621  DVASFVPRDG VLDVEARRQG AAFYAPGREP VPMLPASLCQ DVLSLLPGRD RLAISLFLTM
  1681  EKASGQLKSL RFAPSVVQSD RQLSYEEAEE VIRQHPGAGR ELPARLDSVD ACVVAACYFS
  1741  RLLRRHRLRS DCFYEQPDED GTLGFRAAHI MVKEYMIQFN RLVAEFLVGS ECTRTVTPLR
  1801  WQPAPRSQQL KALCEKHGDR VPLSLHLGHH LHGGGGSPPD TRLHLLASLW KQVQFAARTQ
  1861  DYEQMVDLVT TDDMHPFLAP AGRDLRKALE RSAFGRCARG HQQQGGHYSL QVDWYTWATS
  1921  PIRRYLDVVL QRQILLALGH GGSAYSARDI DGLCQAFSLQ HALAQSYQRR ARSLHLAVQL
  1981  KAQPLDKLGF VVDVEAGSRC FRLLFPSNRE TLPDPCPVPY GSLQLAEHPH ALAGRPGLRL
  2041  LWRRRVYSAQ GSSPPLPLPG TVPDPHTLAV ETALWKQLLE LVELQRWPEA AALIQEKGEA
  2101  SQRRELVQVQ RSHCGHFLEV ARELGSGDTL QVQLGTSLQH GFLVPSPQLW TVAPGFSLCL
  2161  EHVERPGDCF SGRVYRAPRD RYRDVDEYAC VWEPFCALES ATGAVAENDS VTLQHLSVSW
  2221  EASRTPQGQL QGAFRLEAAF LEENCADINF SCCYLCIRLE GLPAPTASPR PGPSSLGPGL
  2281  NVDPGTYTWV AHGQTQDWDQ ERRADRQEAP RRVHLFVHHM GMEKVPEEVL RPGTLFTVEL
  2341  LPKQLPDLRK EEAVRGLEEA SPLVTSIALG RPVPQPLCRV IPSRFLERQT YNIPGGRHKL
  2401  NPSQNVAVRE ALEKPFTVIQ GPPGTGKTIV GLHIVFWFHK SNQEQVQPGG PPRGEKRLGG
  2461  PCILYCGPSN KSVDVLAGLL LRRMELKPLR VYSEQAEASE FPVPRVGSRK LLRKSPREGR
  2521  PNQSLRSITL HHRIRQAPNP YSSEIKAFDT RLQRGELFSR EDLVWYKKVL WEARKFELDR
  2581  HEVILCTCSC AASASLKILD VRQILVDEAG MATEPETLIP LVQFPQAEKV VLLGDHKQLR
  2641  PVVKNERLQN LGLDRSLFER YHEDAHMLDT QYRMHEGICA FPSVAFYKSK LKTWQGLRRP
  2701  PSVLGHAGKE SCPVIFGHVQ GHERSLLVST DEGNENSKAN LEEVAEVVRI TKQLTLGRTV
  2761  EPQDIAVLTP YNAQASEISK ALRREGIAGV AVSSITKSQG SEWRYVLVST VRTCAKSDLD
  2821  QRPTKSWLKK FLGFVVDPNQ VNVAVTRAQE GLCLIGDHLL LRCCPLWRSL LDFCEAQQTL
  2881  VPAGQVRVCR RPTMPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HELZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0

gnomAD missense Z

0.43

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of transcription by RNA polymerase II
• regulatory ncRNA-mediated post-transcriptional gene silencing

Molecular functions

• ATP binding
• ATP hydrolysis activity
• DNA binding
• exoribonuclease II activity
• RNA binding
• RNA helicase activity
• transcription coactivator activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• membrane
• nucleoplasm
• P granule

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CCCH-type
• Ribonuclease II/R
• Nucleic acid-binding, OB-fold
• Ribonuclease II/R, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Zinc finger C2H2 superfamily
• DNA2/NAM7 helicase, helicase domain
• DNA2/NAM7 helicase-like, C-terminal
• Upf1-like, C-terminal helicase domain
• Coronaviruses polyprotein 1ab
• RNB domain
• AAA domain
• AAA domain
• 3'-5' exoribonuclease HELZ2, OB-fold domain
• 3'-5' exoribonuclease HELZ2, OB-fold domain

KeywordsUniProt

• Activator
• ATP-binding
• Cytoplasm
• DNA-binding
• Exonuclease
• Helicase
• Hydrolase
• Metal-binding
• Nuclease
• Nucleotide-binding
• Phosphoprotein
• Repeat
• RNA-binding
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of HELZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPARA
• THRAP3
• PPARG