Seroatlas · Human Serome Atlas

RAB34

Ras-related protein Rab-34

Also known as: NARR, RAB34_HUMAN, RAB39, RAH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZG1
Gene
RAB34
Ensembl
ENSG00000109113
Chromosome
17
Canonical length
259 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Primary cilium,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q9BZG1|RAB34
     1  MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD
    61  LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP FSLQLWDTAG QERFKCIAST
   121  YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLVGSKKDL STPAQYALME
   181  KDALQVAQEM KAEYWAVSSL TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN
   241  SDDSNLYLTA SKKKPTCCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 144 nTPM
  • ovary: 110 nTPM
  • cervix: 106 nTPM
  • endometrium: 97 nTPM
  • adrenal gland: 91 nTPM
  • fallopian tube: 89 nTPM

Single-cell type

  • decidual stromal cells: 221 nCPM
  • peritubular myoid cells: 146 nCPM
  • hepatic stellate cells: 142 nCPM
  • breast myoepithelial cells: 128 nCPM
  • epididymal basal cells: 127 nCPM
  • ovarian stromal cells: 127 nCPM

Immune cell

  • myeloid DC: 76 nTPM
  • classical monocyte: 51 nTPM
  • intermediate monocyte: 47 nTPM
  • plasmacytoid DC: 47 nTPM
  • non-classical monocyte: 24 nTPM
  • total PBMC: 22 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • medulla oblongata: 24 nTPM
  • thalamus: 21 nTPM
  • amygdala: 18 nTPM
  • midbrain: 18 nTPM
  • spinal cord: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB34.

Disease | AllUniProt

Conditions RAB34 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
1.08
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB34 as an antibody target. Whether an autoantibody or antibody against RAB34 could matter depends on whether native RAB34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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