Seroatlas · Human Serome Atlas

HNRNPUL1

Heterogeneous nuclear ribonucleoprotein U-like protein 1

Also known as: E1B-AP5, E1BAP5, FLJ12944, HNRL1_HUMAN, HNRPUL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUJ2
Gene: HNRNPUL1
Ensembl: ENSG00000105323
Chromosome: 19
Canonical length: 856 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

856 residues, UniProt reviewed canonical sequence.

>Q9BUJ2|HNRNPUL1
     1  MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLQAALEAE EPDDERELDA DDEPGRPGHI
    61  NEEVETEGGS ELEGTAQPPP PGLQPHAEPG GYSGPDGHYA MDNITRQNQF YDTQVIKQEN
   121  ESGYERRPLE MEQQQAYRPE MKTEMKQGAP TSFLPPEASQ LKPDRQQFQS RKRPYEENRG
   181  RGYFEHREDR RGRSPQPPAE EDEDDFDDTL VAIDTYNCDL HFKVARDRSS GYPLTIEGFA
   241  YLWSGARASY GVRRGRVCFE MKINEEISVK HLPSTEPDPH VVRIGWSLDS CSTQLGEEPF
   301  SYGYGGTGKK STNSRFENYG DKFAENDVIG CFADFECGND VELSFTKNGK WMGIAFRIQK
   361  EALGGQALYP HVLVKNCAVE FNFGQRAEPY CSVLPGFTFI QHLPLSERIR GTVGPKSKAE
   421  CEILMMVGLP AAGKTTWAIK HAASNPSKKY NILGTNAIMD KMRVMGLRRQ RNYAGRWDVL
   481  IQQATQCLNR LIQIAARKKR NYILDQTNVY GSAQRRKMRP FEGFQRKAIV ICPTDEDLKD
   541  RTIKRTDEEG KDVPDHAVLE MKANFTLPDV GDFLDEVLFI ELQREEADKL VRQYNEEGRK
   601  AGPPPEKRFD NRGGGGFRGR GGGGGFQRYE NRGPPGGNRG GFQNRGGGSG GGGNYRGGFN
   661  RSGGGGYSQN RWGNNNRDNN NSNNRGSYNR APQQQPPPQQ PPPPQPPPQQ PPPPPSYSPA
   721  RNPPGASTYN KNSNIPGSSA NTSTPTVSSY SPPQPSYSQP PYNQGGYSQG YTAPPPPPPP
   781  PPAYNYGSYG GYNPAPYTPP PPPTAQTYPQ PSYNQYQQYA QQWNQYYQNQ GQWPPYYGNY
   841  DYGSYSGNTQ GGTSTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HNRNPUL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 166 nTPM
thymus: 130 nTPM
tonsil: 103 nTPM
ovary: 98 nTPM
lymph node: 96 nTPM
skeletal muscle: 87 nTPM

Single-cell type

innate lymphoid cells: 209 nCPM
monocyte progenitors: 199 nCPM
t-cells: 169 nCPM
plasma cells: 164 nCPM
pdcs: 160 nCPM
neutrophil progenitors: 147 nCPM

Immune cell

MAIT T-cell: 13 nTPM
plasmacytoid DC: 11 nTPM
memory CD4 T-cell: 10 nTPM
eosinophil: 9.8 nTPM
NK-cell: 9.6 nTPM
memory CD8 T-cell: 9.4 nTPM

Brain region

medulla oblongata: 116 nTPM
cerebellum: 113 nTPM
white matter: 113 nTPM
cerebral cortex: 111 nTPM
basal ganglia: 108 nTPM
choroid plexus: 103 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.23
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HNRNPUL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HNRNPUL1 as an antibody target. Whether an autoantibody or antibody against HNRNPUL1 could matter depends on whether native HNRNPUL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HNRNPUL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HNRNPUL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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