Seroatlas · Human Serome Atlas

AQR

RNA helicase aquarius

Also known as: AQR_HUMAN, fSAP164, IBP160, KIAA0560

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60306
Gene: AQR
Ensembl: ENSG00000021776
Chromosome: 15
Canonical length: 1485 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1485 residues, UniProt reviewed canonical sequence.

>O60306|AQR
     1  MAAPAQPKKI VAPTVSQINA EFVTQLACKY WAPHIKKKSP FDIKVIEDIY EKEIVKSRFA
    61  IRKIMLLEFS QYLENYLWMN YSPEVSSKAY LMSICCMVNE KFRENVPAWE IFKKKPDHFP
   121  FFFKHILKAA LAETDGEFSL HEQTVLLLFL DHCFNSLEVD LIRSQVQQLI SLPMWMGLQL
   181  ARLELELKKT PKLRKFWNLI KKNDEKMDPE AREQAYQERR FLSQLIQKFI SVLKSVPLSE
   241  PVTMDKVHYC ERFIELMIDL EALLPTRRWF NTILDDSHLL VHCYLSNLVR REEDGHLFSQ
   301  LLDMLKFYTG FEINDQTGNA LTENEMTTIH YDRITSLQRA AFAHFPELYD FALSNVAEVD
   361  TRESLVKFFG PLSSNTLHQV ASYLCLLPTL PKNEDTTFDK EFLLELLVSR HERRISQIQQ
   421  LNQMPLYPTE KIIWDENIVP TEYYSGEGCL ALPKLNLQFL TLHDYLLRNF NLFRLESTYE
   481  IRQDIEDSVS RMKPWQSEYG GVVFGGWARM AQPIVAFTVV EVAKPNIGEN WPTRVRADVT
   541  INLNVRDHIK DEWEGLRKHD VCFLITVRPT KPYGTKFDRR RPFIEQVGLV YVRGCEIQGM
   601  LDDKGRVIED GPEPRPNLRG ESRTFRVFLD PNQYQQDMTN TIQNGAEDVY ETFNIIMRRK
   661  PKENNFKAVL ETIRNLMNTD CVVPDWLHDI ILGYGDPSSA HYSKMPNQIA TLDFNDTFLS
   721  IEHLKASFPG HNVKVTVEDP ALQIPPFRIT FPVRSGKGKK RKDADVEDED TEEAKTLIVE
   781  PHVIPNRGPY PYNQPKRNTI QFTHTQIEAI RAGMQPGLTM VVGPPGTGKT DVAVQIISNI
   841  YHNFPEQRTL IVTHSNQALN QLFEKIMALD IDERHLLRLG HGEEELETEK DFSRYGRVNY
   901  VLARRIELLE EVKRLQKSLG VPGDASYTCE TAGYFFLYQV MSRWEEYISK VKNKGSTLPD
   961  VTEVSTFFPF HEYFANAPQP IFKGRSYEED MEIAEGCFRH IKKIFTQLEE FRASELLRSG
  1021  LDRSKYLLVK EAKIIAMTCT HAALKRHDLV KLGFKYDNIL MEEAAQILEI ETFIPLLLQN
  1081  PQDGFSRLKR WIMIGDHHQL PPVIKNMAFQ KYSNMEQSLF TRFVRVGVPT VDLDAQGRAR
  1141  ASLCNLYNWR YKNLGNLPHV QLLPEFSTAN AGLLYDFQLI NVEDFQGVGE SEPNPYFYQN
  1201  LGEAEYVVAL FMYMCLLGYP ADKISILTTY NGQKHLIRDI INRRCGNNPL IGRPNKVTTV
  1261  DRFQGQQNDY ILLSLVRTRA VGHLRDVRRL VVAMSRARLG LYIFARVSLF QNCFELTPAF
  1321  SQLTARPLHL HIIPTEPFPT TRKNGERPSH EVQIIKNMPQ MANFVYNMYM HLIQTTHHYH
  1381  QTLLQLPPAM VEEGEEVQNQ ETELETEEEA MTVQADIIPS PTDTSCRQET PAFQTDTTPS
  1441  ETGATSTPEA IPALSETTPT VVGAVSAPAE ANTPQDATSA PEETK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

retina: 7.4 nTPM
thymus: 6.5 nTPM
cerebellum: 5.9 nTPM
breast: 5.5 nTPM
cervix: 5.3 nTPM
testis: 5.2 nTPM

Single-cell type

cone photoreceptor cells: 137 nCPM
bergmann glia: 136 nCPM
neutrophil progenitors: 116 nCPM
pituitary stem cells: 98 nCPM
rod photoreceptor cells: 94 nCPM
b-cells: 91 nCPM

Immune cell

basophil: 3.6 nTPM
gdT-cell: 2.6 nTPM
memory CD8 T-cell: 2.6 nTPM
naive CD8 T-cell: 2.6 nTPM
MAIT T-cell: 2.3 nTPM
memory CD4 T-cell: 2.3 nTPM

Brain region

cerebellum: 19 nTPM
basal ganglia: 14 nTPM
white matter: 14 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 3.55
DepMap mean gene effect: -1.56
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
DNA2/NAM7 helicase, helicase domain
DNA2/NAM7 helicase-like, C-terminal
DNA2/NAM7-like helicase
Upf1-like, C-terminal helicase domain
AAA domain
AAA domain
CWF11 family
RNA helicase aquarius, N-terminal domain
RNA helicase aquarius, beta-barrel
RNA helicase aquarius, insertion domain
Intron-binding protein aquarius N-terminal
Intron-binding protein aquarius, beta-barrel
Intron-binding protein aquarius insert domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AQR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQR as an antibody target. Whether an autoantibody or antibody against AQR could matter depends on whether native AQR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AQR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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