RERG
Ras-related and estrogen-regulated growth inhibitor
Also known as: MGC15754, RERG_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96A58
- Gene
- RERG
- Ensembl
- ENSG00000134533
- Chromosome
- 12
- Canonical length
- 199 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center,Cytosol
OverviewNCBI Gene
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
Canonical amino-acid sequenceUniProt
199 residues, UniProt reviewed canonical sequence.
>Q96A58|RERG
1 MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID DEVVSMEILD
61 TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN ILDEIKKPKN VTLILVGNKA
121 DLDHSRQVST EEGEKLATEL ACAFYECSAC TGEGNITEIF YELCREVRRR RMVQGKTRRR
181 SSTTHVKQAI NKMLTKISSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RERG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 94 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 94 nTPM
- smooth muscle: 78 nTPM
- fallopian tube: 76 nTPM
- seminal vesicle: 73 nTPM
- blood vessel: 49 nTPM
- epididymis: 48 nTPM
Single-cell type
- podocytes: 1,212 nCPM
- proximal tubule cells: 508 nCPM
- salivary ionocytes: 493 nCPM
- mesothelial cells: 412 nCPM
- pericytes: 407 nCPM
- adrenal cortex cells: 401 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- pons: 39 nTPM
- basal ganglia: 39 nTPM
- medulla oblongata: 29 nTPM
- cerebral cortex: 22 nTPM
- midbrain: 21 nTPM
- hypothalamus: 21 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.28
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.35
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of cell growth
- negative regulation of cell population proliferation
- response to hormone
- small GTPase-mediated signal transduction
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RERG as an antibody target. Whether an autoantibody or antibody against RERG could matter depends on whether native RERG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RERG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RERG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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