Seroatlas · Human Serome Atlas

LRGUK

Leucine-rich repeat and guanylate kinase domain-containing protein

Also known as: CFAP246, FLJ32786, LRGUK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M69
Gene: LRGUK
Ensembl: ENSG00000155530
Chromosome: 7
Canonical length: 825 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

825 residues, UniProt reviewed canonical sequence.

>Q96M69|LRGUK
     1  MATSERALLR TRAASLLRGL GRSRTGARSL QFRAEKERQP CWSFPMGQKT KGSSNIASSY
    61  LLQQLMHRYQ ELDSDGDEDQ GEGEAGSEES SESEMLNLEE EFDGVLREEA VAKALHHLGR
   121  SGSGTEQVYL NLTLSGCNLI DVSILCGYVH LQKLDLSANK IEDLSCVSCM PYLLELNASQ
   181  NNLTTFFNFK PPKNLKKADF SHNQISEICD LSAYHALTKL ILDGNEIEEI SGLEMCNNLI
   241  HLSLANNKIT TINGLNKLPI KILCLSNNQI EMITGLEDLK ALQNLDLSHN QISSLQGLEN
   301  HDLLEVINLE DNKIAELREI EYIKNLPILR VLNLLENPIQ EKSEYWFFVI FMLLRLTELD
   361  QKKIKVEEKV SAVNKYDPPP EVVAAQDHLT HVVNSVMQPQ RIFDSTLPSL DAPYPMLILA
   421  GPEACGKREL AHRLCRQFST YFRYGACHTT RPPYFGEGDR VDYHFISQDV FDEMVNMGKF
   481  ILTFSYGNHK YGLNRDTVEG IARDGLASCI HMEIEGVRSL KYSYFEPRYI LVVPMNKEKY
   541  EGYLRRKGLF SRAEIEFAVS RVDLYIKINQ NFPGYFDEVI NADDLDVAYQ KLSQLIREYL
   601  GLTEEPAKSL ATTADVKTSH LKPEAHPTKY ISSNMGDFLH STDRNYLIKF WAKLSAKKTP
   661  AERDSIHRQH EAARQALMGR IRPDHTLLFQ RGPVPAPLTS GLHYYTTLEE LWKSFDLCED
   721  YFKPPFGPYP EKSGKDSLVS MKCSLFRFCP WSKELPFQPP EGSISSHLGS GASDSETEET
   781  RKALPIQSFS HEKESHQHRQ HSVPVISRPG SNVKPTLPPI PQGRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRGUK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

testis: 4.8 nTPM
fallopian tube: 3.8 nTPM
choroid plexus: 3.1 nTPM
retina: 2.4 nTPM
epididymis: 1.5 nTPM
pancreas: 0.9 nTPM

Single-cell type

ependymal cells: 544 nCPM
respiratory ciliated cells: 374 nCPM
endometrial ciliated cells: 295 nCPM
epididymal efferent duct ciliated cells: 205 nCPM
fallopian tube ciliated cells: 200 nCPM
choroid plexus epithelial cells: 162 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 17 nTPM
medulla oblongata: 12 nTPM
midbrain: 11 nTPM
spinal cord: 6.9 nTPM
hypothalamus: 6.5 nTPM
hippocampal formation: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRGUK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRGUK as an antibody target. Whether an autoantibody or antibody against LRGUK could matter depends on whether native LRGUK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRGUK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRGUK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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