Seroatlas · Human Serome Atlas

SEPTIN14

Septin-14

Also known as: FLJ44060, SEP14_HUMAN, SEPT14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZU15
Gene: SEPTIN14
Ensembl: ENSG00000154997
Chromosome: 7
Canonical length: 432 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q6ZU15|SEPTIN14
     1  MAERTMAMPT QIPADGDTQK ENNIRCLTTI GHFGFECLPN QLVSRSIRQG FTFNILCVGE
    61  TGIGKSTLID TLFNTNLKDN KSSHFYSNVG LQIQTYELQE SNVQLKLTVV ETVGYGDQID
   121  KEASYQPIVD YIDAQFEAYL QEELKIKRSL FEYHDSRVHV CLYFISPTGH SLKSLDLLTM
   181  KNLDSKVNII PLIAKADTIS KNDLQTFKNK IMSELISNGI QIYQLPTDEE TAAQANSSVS
   241  GLLPFAVVGS TDEVKVGKRM VRGRHYPWGV LQVENENHCD FVKLRDMLLC TNMENLKEKT
   301  HTQHYECYRY QKLQKMGFTD VGPNNQPVSF QEIFEAKRQE FYDQCQREEE ELKQRFMQRV
   361  KEKEATFKEA EKELQDKFEH LKMIQQEEIR KLEEEKKQLE GEIIDFYKMK AASEALQTQL
   421  STDTKKDKHR KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
bone marrow: 2.2 nTPM
liver: 2.1 nTPM
retina: 1.9 nTPM
appendix: 1.4 nTPM
pituitary gland: 1.3 nTPM

Single-cell type

sertoli cells: 599 nCPM
somatotrophs: 100 nCPM
undifferentiated spermatogonia: 11 nCPM
early spermatids: 6 nCPM
late spermatids: 6 nCPM
late primary spermatocytes: 5.6 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
NK-cell: 0.2 nTPM
naive B-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 5.5 nTPM
cerebellum: 5.3 nTPM
hypothalamus: 5.1 nTPM
white matter: 5 nTPM
basal ganglia: 4.9 nTPM
pons: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN14 as an antibody target. Whether an autoantibody or antibody against SEPTIN14 could matter depends on whether native SEPTIN14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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