EIF4A2
Eukaryotic initiation factor 4A-II
Also known as: BM-010, DDX2B, EIF4A, EIF4F, IF4A2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q14240
- Gene
- EIF4A2
- Ensembl
- ENSG00000156976
- Chromosome
- 3
- Canonical length
- 407 aa
- Protein class
- Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables ATP hydrolysis activity. Involved in negative regulation of RNA-dependent RNA polymerase activity. Located in perinuclear region of cytoplasm. Implicated in neurodevelopmental disorder with hypotonia and speech delay. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
407 residues, UniProt reviewed canonical sequence.
>Q14240|EIF4A2
1 MSGGSADYNR EHGGPEGMDP DGVIESNWNE IVDNFDDMNL KESLLRGIYA YGFEKPSAIQ
61 QRAIIPCIKG YDVIAQAQSG TGKTATFAIS ILQQLEIEFK ETQALVLAPT RELAQQIQKV
121 ILALGDYMGA TCHACIGGTN VRNEMQKLQA EAPHIVVGTP GRVFDMLNRR YLSPKWIKMF
181 VLDEADEMLS RGFKDQIYEI FQKLNTSIQV VLLSATMPTD VLEVTKKFMR DPIRILVKKE
241 ELTLEGIKQF YINVEREEWK LDTLCDLYET LTITQAVIFL NTRRKVDWLT EKMHARDFTV
301 SALHGDMDQK ERDVIMREFR SGSSRVLITT DLLARGIDVQ QVSLVINYDL PTNRENYIHR
361 IGRGGRFGRK GVAINFVTEE DKRILRDIET FYNTTVEEMP MNVADLILocalizationUniProt · AlphaFold · HPA
Whether an antibody against EIF4A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 655 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 655 nTPM
- ovary: 539 nTPM
- tongue: 517 nTPM
- cerebellum: 494 nTPM
- cerebral cortex: 462 nTPM
- heart muscle: 359 nTPM
Single-cell type
- esophageal apical cells: 1,755 nCPM
- parietal cells: 845 nCPM
- ovarian stromal cells: 812 nCPM
- syncytiotrophoblasts: 766 nCPM
- decidual stromal cells: 749 nCPM
- gastric chief cells: 746 nCPM
Immune cell
- total PBMC: 282 nTPM
- naive CD4 T-cell: 274 nTPM
- memory B-cell: 246 nTPM
- basophil: 233 nTPM
- naive CD8 T-cell: 225 nTPM
- naive B-cell: 204 nTPM
Brain region
- hypothalamus: 367 nTPM
- cerebellum: 356 nTPM
- cerebral cortex: 314 nTPM
- basal ganglia: 301 nTPM
- pons: 278 nTPM
- white matter: 242 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about EIF4A2.
Disease | AllUniProt
Conditions EIF4A2 is implicated in, by any mechanism.
- Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures (NEDHSS) MIM:620455
Disease | GeneticClinVar
19 pathogenic / likely-pathogenic of 118 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures
- Neurodevelopmental disorder
- Inborn genetic diseases
- Intellectual disability with muscular spams
- Neurodevelopmental delay
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.21
- gnomAD pLI
- 1
- gnomAD missense Z
- 3.9
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to leukemia inhibitory factor
- cytoplasmic translational initiation
- regulation of translational initiation
- translational initiation
- negative regulation of RNA-dependent RNA polymerase activity
Molecular functions
- ATP binding
- ATP hydrolysis activity
- helicase activity
- RNA binding
- RNA helicase activity
- translation initiation factor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ATP-dependent RNA helicase DEAD-box, conserved site
- Helicase, C-terminal domain-like
- DEAD/DEAH-box helicase domain
- Helicase superfamily 1/2, ATP-binding domain
- RNA helicase, DEAD-box type, Q motif
- P-loop containing nucleoside triphosphate hydrolase
- ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain
- DEAD/DEAH box helicase
- Helicase conserved C-terminal domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of EIF4A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EIF4A2 as an antibody target. Whether an autoantibody or antibody against EIF4A2 could matter depends on whether native EIF4A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EIF4A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EIF4A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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